{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:04:05Z","timestamp":1792735445503,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T00:00:00Z","timestamp":1527033600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hyaluronic acid (<jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>) and platelet\u2010rich plasma (<jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content>) are two treatment options used for knee osteoarthritis (<jats:styled-content style=\"fixed-case\">KOA<\/jats:styled-content>) but studies comparing the efficacy of the two yield conflicting results. In addition, the association of clinical outcomes of <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> intra\u2010articular injections with changes in the ultrasonography structural appearance of the knee has not been investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the efficacy of <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content> intra\u2010articular injections as mono\u2010therapeutic options for primary <jats:styled-content style=\"fixed-case\">KOA<\/jats:styled-content>, and to determine whether the clinical outcomes are associated with changes in the ultrasonography structural appearance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and methods<\/jats:title><jats:p>A randomized clinical trial was conducted on 89 patients with <jats:styled-content style=\"fixed-case\">KOA<\/jats:styled-content>. The patients were given either <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>45) or <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content> (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>44) intra\u2010articular injections. The patients received three injections in the knee, which was more symptomatic at baseline evaluation, with a 2\u2010week interval between injections. The outcome measures included visual analog score \u2013 pain, International Knee Documentation Committee Score, and assessment of synovial hypertrophy, synovial vascularity and knee effusion using ultrasonography. Outcome measures were assessed at baseline and at 3 and 6\u00a0months post\u2010injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>While both <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content> injections resulted in the improvement of all outcome measures at 3 and 6\u00a0months follow up, they were significantly better in the <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> group than in the <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content> group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intra\u2010articular injection of <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> is an effective treatment that reduced pain and improved functional status in patients with <jats:styled-content style=\"fixed-case\">KOA<\/jats:styled-content>. The clinical outcomes of the intra\u2010articular injections of <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> are associated with improved synovial hypertrophy and vascularity scores, and less effusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13315","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T21:44:42Z","timestamp":1527803082000},"page":"960-966","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Clinical outcomes are associated with changes in ultrasonographic structural appearance after platelet\u2010rich plasma treatment for knee osteoarthritis"],"prefix":"10.1111","volume":"21","author":[{"given":"Hamada S.","family":"Ahmad","sequence":"first","affiliation":[{"name":"Rheumatology and Rehabilitation Department Mansoura Faculty of Medicine Mansoura University Mansoura 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