{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:58:23Z","timestamp":1793069903060,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T00:00:00Z","timestamp":1528243200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K19604"],"award-info":[{"award-number":["16K19604"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24790999"],"award-info":[{"award-number":["24790999"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["16810055"],"award-info":[{"award-number":["16810055"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>To determine the effect of leuprolide acetate, a synthetic gonadotropin\u2010releasing hormone analog (GnRH<\/jats:styled-content>\u2010a) on ovarian function preservation in systemic lupus erythematosus (SLE<\/jats:styled-content>) patients treated with cyclophosphamide (CYC<\/jats:styled-content>) in clinical practice.<\/jats:p><\/jats:sec>Methods<\/jats:title>We enrolled 30 premenopausal female SLE<\/jats:styled-content> patients who fulfilled the 1997 American College of Rheumatology revised criteria and were treated with intravenous CYC<\/jats:styled-content> (IVCY<\/jats:styled-content>) in 2008\u20132017. We used Kaplan\u2013Meier survival estimates to compare the GnRH<\/jats:styled-content>\u2010a\u2010treated patients and those not treated with GnRH<\/jats:styled-content>\u2010a as controls. We performed Cox regression analyses to identify factors associated with premature ovarian failure (POF<\/jats:styled-content>), incidences of cardiovascular events, strokes and osteoporosis after IVCY<\/jats:styled-content> therapy.<\/jats:p><\/jats:sec>Results<\/jats:title>After a mean follow\u2010up of 41\u00a0months, POF<\/jats:styled-content> developed in one of the 16 GnRH<\/jats:styled-content>\u2010a\u2010treated patients (6%) versus seven of the 14 controls (50%). Significantly improved cumulative ovarian protection over time was observed in the GnRH<\/jats:styled-content>\u2010a\u2010treated group (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.030). The hazard model analysis showed that treatment with GnRH<\/jats:styled-content>\u2010a during IVCY<\/jats:styled-content> therapy is an independent factor associated with POF<\/jats:styled-content> after IVCY<\/jats:styled-content> therapy (adjusted hazards ratio\u00a0=\u00a00.12, 95% CI<\/jats:styled-content> 0.01\u20130.67, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.013) but not incidences of cardiovascular events, strokes or osteoporosis.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The combined use of GnRH<\/jats:styled-content>\u2010a with IVCY<\/jats:styled-content> therapy was associated with a significant reduction of POF<\/jats:styled-content> among premenopausal women with SLE<\/jats:styled-content>, suggesting that the addition of GnRH<\/jats:styled-content>\u2010a can be a strategy to prevent POF<\/jats:styled-content> among premenopausal women with SLE<\/jats:styled-content> after IVCY<\/jats:styled-content> therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13318","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T16:29:46Z","timestamp":1528388986000},"page":"1287-1292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Effect of a gonadotropin\u2010releasing hormone analog for ovarian function preservation after intravenous cyclophosphamide therapy in systemic lupus erythematosus patients: a retrospective inception cohort study"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2077-4428","authenticated-orcid":false,"given":"Tomohiro","family":"Koga","sequence":"first","affiliation":[{"name":"Division of Advanced Preventive Medical Sciences Department of Immunology and Rheumatology Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan"},{"name":"Center for Bioinformatics and Molecular Medicine Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6647-7130","authenticated-orcid":false,"given":"Masataka","family":"Umeda","sequence":"additional","affiliation":[{"name":"Division of Advanced Preventive Medical Sciences Department of Immunology and Rheumatology Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan"},{"name":"Medical Education Development Center Nagasaki University Hospital Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushiro","family":"Endo","sequence":"additional","affiliation":[{"name":"Division of Advanced Preventive Medical Sciences Department of Immunology and Rheumatology Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midori","family":"Ishida","sequence":"additional","affiliation":[{"name":"Division of Advanced Preventive 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