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Gene functional investigations have revealed the particular relevance of <jats:italic><jats:styled-content style=\"fixed-case\">ORMDL<\/jats:styled-content>3<\/jats:italic> in endoplasmic reticulum stress, lipid metabolism and inflammatory reactions. Additionally, several reports have recently added a new dimension to our understanding of the modulation of <jats:italic><jats:styled-content style=\"fixed-case\">ORMDL<\/jats:styled-content>3<\/jats:italic> gene expression in inflammation. This mini\u2010review summarizes the pertinent publications regarding the genetic association studies and mechanistic exploration of <jats:italic><jats:styled-content style=\"fixed-case\">ORMDL<\/jats:styled-content>3<\/jats:italic> in common inflammatory disorders.<\/jats:p>","DOI":"10.1111\/1756-185x.13324","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T16:29:46Z","timestamp":1528388986000},"page":"1154-1162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["<scp>ORMDL<\/scp>3 and its implication in inflammatory disorders"],"prefix":"10.1111","volume":"21","author":[{"given":"Xiaochun","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery Shandong Provincial Hospital affiliated to Shandong University Jinan China"},{"name":"Key Laboratory for Experimental Teratology of the Ministry of Education and Department of Medical Genetics Shandong 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