{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T05:47:04Z","timestamp":1775886424554,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T00:00:00Z","timestamp":1530489600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Systemic sclerosis (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c) can present as an overlap syndrome with rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c\u2010<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> overlap).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the frequency of rheumatoid factor (<jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content>) and anticyclic citrullinated peptide antibodies (anti\u2010<jats:styled-content style=\"fixed-case\">CCP<\/jats:styled-content>) in our <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c cohort and their association with clinical features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were gathered prospectively from the Waikato Hospital Systemic Sclerosis Clinics. Patients with <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c and <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content> (systemic sclerosis overlap syndrome) underwent baseline auto\u2010antibody profiling including <jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content> and anti\u2010<jats:styled-content style=\"fixed-case\">CCP<\/jats:styled-content> along with annual clinical review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our cohort comprised of 132 patients (two had incomplete data); 115 (87.1%) were female. Out of 89 limited cutaneous <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c (lc<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c) patients, arthralgia, synovitis, contractures, tendon crepitus and erosions on imaging were found in three, 10, 31, five and nine patients, respectively. Within the 33 diffuse cutaneous <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c (dc<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c) patients, arthralgia, synovitis, contractures, tendon crepitus and erosion were found in 15, five, 27, five and one patient, respectively. In the 10 <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content> patients, arthralgia, synovitis and contractures were found in six, three and two patients; none had tendon crepitus or erosions. <jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content> positivity was found in 15.7%, 9% and 20% of patients with lc<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c, dc<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c and <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content>, and anti\u2010<jats:styled-content style=\"fixed-case\">CCP<\/jats:styled-content> positivity was found in 13.5%, 6.1% and 0% in lc<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c, dc<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c and <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content> patients. A statistically significant relationship of double antibody positivity with arthralgia (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) and erosions (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) was found. Anti\u2010<jats:styled-content style=\"fixed-case\">CCP<\/jats:styled-content> positivity association with erosions was significant at <jats:italic>P<\/jats:italic>\u00a0=\u00a00.007.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study confirms that articular manifestations are common in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c. Statistically significant associations of double antibody positivity with arthralgia and erosions were demonstrated. Significant association between anti\u2010<jats:styled-content style=\"fixed-case\">CCP<\/jats:styled-content> antibody and erosions was also confirmed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13330","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T06:17:26Z","timestamp":1530598646000},"page":"1430-1435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Significance of combined anti\u2010<scp>CCP<\/scp> antibodies and rheumatoid factor in a New Zealand cohort of patients with systemic sclerosis"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6296-0734","authenticated-orcid":false,"given":"Sujatha","family":"Kamalaksha","sequence":"first","affiliation":[{"name":"Rheumatology Department Waikato Hospital Hamilton New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas H. 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