{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T17:11:33Z","timestamp":1783357893119,"version":"3.54.6"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T00:00:00Z","timestamp":1535587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Current studies demonstrate red blood cell distribution width (<jats:styled-content style=\"fixed-case\">RDW<\/jats:styled-content>) as a possible surrogate biomarker of inflammation. The objectives of the present study were to examine <jats:styled-content style=\"fixed-case\">RDW<\/jats:styled-content> in patients with osteoarthritis (<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>), fibromyalgia (<jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content>), rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>) and spondyloarthritis (SpA) and to evaluate its clinical importance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six hundred and ninety\u2010nine ambulatory patients were evaluated. <jats:styled-content style=\"fixed-case\">RDW<\/jats:styled-content>, hemoglobin, erythrocyte sedimentation rate (<jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content>) and C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>) were assessed. In order to compare groups, a Kruskall\u2013Wallis test with <jats:italic>post hoc<\/jats:italic> Dunn's test was applied. A multiple logistic regression analysis was used to evaluate anisocytosis explanatory variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Red blood cell distribution width values differed significantly among groups. <jats:italic>Post hoc<\/jats:italic> analysis demonstrated a significant increase in <jats:styled-content style=\"fixed-case\">RDW<\/jats:styled-content> within <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> versus <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> groups (<jats:italic>P<\/jats:italic> &lt; 0.001), active SpA versus <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> (<jats:italic>P<\/jats:italic> &lt; 0.001), <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> versus <jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content> (<jats:italic>P<\/jats:italic> &lt; 0.001) and active SpA versus <jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content> groups (<jats:italic>P<\/jats:italic> = 0.001). Presence of anisocytosis was useful to discriminate between active articular inflammatory versus non\u2010inflammatory diseases with 48\u201395% sensitivity and 66\u201395% specificity. Multivariate analysis showed a six\u2010fold increase in anisocytosis for the presence of a possible articular inflammatory disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In subjects with articular pain, <jats:styled-content style=\"fixed-case\">RDW<\/jats:styled-content> interpretation is a useful tool in clinical practice to distinguish between articular inflammatory and non\u2010inflammatory joint diseases, as with <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">RDW<\/jats:styled-content> seems to be a surrogate marker of the inflammatory process.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13332","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T07:23:03Z","timestamp":1535700183000},"page":"47-54","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Clinical utility of red 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