{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T01:01:52Z","timestamp":1784336512453,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T00:00:00Z","timestamp":1530489600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81128012"],"award-info":[{"award-number":["81128012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study investigated the common initial clinical presentations of primary Sj\u00f6gren's syndrome (pSS) with interstitial lung disease (ILD) and explored differences between sicca and non\u2010sicca onset pSS\u2010ILD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A total of 1341 SS patients hospitalized between 2003 and 2012 were retrospectively reviewed. Of them, 102 were analyzed and recruited to examine the differences between non\u2010sicca and sicca onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010one percent of pSS\u2010ILD patients presented with non\u2010sicca onset. Although the mean diagnosis time was equal, only 4% of non\u2010sicca onset patients were diagnosed with pSS at onset versus 34% with sicca onset (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.000). Hyperglobulinemia, elevated rheumatoid factor (RF) titer, and anti\u2010SSA and\/or anti\u2010SSB presence were less predominant in patients with non\u2010sicca onset (immunoglobulin G, 16 [12\u201321] <jats:italic>vs<\/jats:italic>. 21 [15\u201328] g\/L, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.032; RF, 22 [20\u2013171] <jats:italic>vs<\/jats:italic>. 104 [20\u2013237] IU\/mL, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.048; anti\u2010SSA and\/or anti\u2010SSB presence, 33% <jats:italic>vs<\/jats:italic>. 72%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.000). The usual interstitial pneumonia pattern was more commonly seen in non\u2010sicca onset patients (20.0% <jats:italic>vs<\/jats:italic>. 14.3%). The high\u2010resolution computed tomography score was higher (12 [88\u201315] <jats:italic>vs<\/jats:italic>. 8 [5\u201313], <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.070) and predicted total lung capacity and forced vital capacity were lower (87\u00a0\u00b1\u00a023% <jats:italic>vs<\/jats:italic>. 97\u00a0\u00b1\u00a020%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.050; 88\u00a0\u00b1\u00a028% <jats:italic>vs<\/jats:italic>. 100\u00a0\u00b1\u00a027%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.089) in non\u2010sicca patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Non\u2010sicca is a common initial manifestation in pSS\u2010ILD. Anti\u2010SSA presence, elevated RF titer and hyperglobulinemia were less predominant, and pulmonary complications were more progressive and severe in non\u2010sicca onset patients than sicca onset patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13334","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T06:17:26Z","timestamp":1530598646000},"page":"1423-1429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Interstitial lung disease in non\u2010sicca onset primary Sj\u00f6gren's syndrome: a large\u2010scale case\u2010control study"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3303-9767","authenticated-orcid":false,"given":"Hui","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Peking University People's Hospital Beijing China"},{"name":"Department of Rheumatology and Immunology Peking University International Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010dan","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Peking University People's Hospital Beijing China"},{"name":"Department of Rheumatology and Immunology Peking University International Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue\u2010wu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Peking University People's Hospital Beijing China"},{"name":"Department of Rheumatology and Immunology Peking University International Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Peking University People's Hospital Beijing 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