{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:45:20Z","timestamp":1790520320476,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T00:00:00Z","timestamp":1536105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Japan Osteoporosis Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Patients with rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>) show lower muscle mass and a higher prevalence of sarcopenia than healthy individuals. Correlations between sarcopenia and disease activity, physical function, laboratory data and body composition at baseline were investigated in a prospective, observational study (<jats:styled-content style=\"fixed-case\">CHIKARA<\/jats:styled-content> study) of <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Body composition was measured using a bioelectrical impedance analyzer. Parameters were compared between sarcopenia and non\u2010sarcopenia groups, and correlations between sarcopenia and Disease Activity Score of 28 joints \u2013 erythrocyte sedimentation rate (<jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28\u2010<jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content>), modified health assessment questionnaire, treatment, and laboratory data, including matrix metalloproteinase 3 (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>3), were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The participants were 100 patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> (women, 78%; mean age, 66.1\u00a0years). Mean disease duration was 5.5\u00a0years, <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28\u2010<jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content> was 3.55 and the prevalence of sarcopenia was 28%. Median C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>3 were significantly higher in the sarcopenia group (0.21\u00a0mg\/dL and 103.4\u00a0ng\/mL) than in the non\u2010sarcopenia group (0.11\u00a0mg\/dL and 70.3\u00a0ng\/mL). Sarcopenia was negatively correlated with weight, body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>), muscle mass, body fat mass, estimated bone mass and basal metabolic rate, and positively correlated with Steinbrocker stage, <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>3 on univariate analyses. <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, body fat mass and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>3 were independently associated with sarcopenia on multivariate logistic regression analysis. When <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>3 was \u2265\u00a090.7\u00a0ng\/mL, the odds ratio for sarcopenia was increased 3.1\u2010fold compared with &lt;\u00a090.7\u00a0ng\/mL (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.018).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of sarcopenia was 28% in patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> whose disease activity was mild. Low <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, high fat mass and high <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>3 were independently associated with sarcopenia. <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>3 might be a useful marker for sarcopenia in patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13335","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T05:57:58Z","timestamp":1536213478000},"page":"1962-1969","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Matrix metalloprotease 3 is associated with sarcopenia in rheumatoid arthritis \u2010 results from the <scp>CHIKARA<\/scp> 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