{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:17:10Z","timestamp":1787242630095,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T00:00:00Z","timestamp":1535587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002966","name":"Cumhuriyet \u00dcniversitesi","doi-asserted-by":"publisher","award":["T\u2010702"],"award-info":[{"award-number":["T\u2010702"]}],"id":[{"id":"10.13039\/501100002966","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      Functional polymorphisms located in\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">FOXP<\/jats:styled-content>\n                        3\n                      <\/jats:italic>\n                      intron 1 was recently found to be associated with rheumatoid arthritis (\n                      <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\n                      ). Although\n                      <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\n                      is an autoimmune disease, there is supporting evidence that activated maladaptive responses including pro\u2010inflammatory pathways play roles in osteoarthritis (\n                      <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\n                      ), similar to\n                      <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\n                      . The aim of this study was to explore the relationship between rs2232365 (\u2010924A\/G) and rs3761548 (\u20103279A\/C) polymorphisms as well as possible changes in the 600 bp promoter region of\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">FOXP<\/jats:styled-content>\n                        3\n                      <\/jats:italic>\n                      and knee\n                      <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients with primary knee\n                      <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      = 300) and healthy individuals (\n                      <jats:italic>n<\/jats:italic>\n                      = 300) were examined for rs3761548 and rs2232365\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">FOXP<\/jats:styled-content>\n                        3\n                      <\/jats:italic>\n                      gene polymorphisms by the polymerase chain reaction\u2013restriction fragment\u2010length polymorphism method. The 600 bp promoter region (between \u2212500 and +100) of the gene was also sequenced with direct sequencing in 50 knee\n                      <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\n                      patients and 50 healthy individuals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were no sequence variants in the promoter region tested both in\n                      <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\n                      patients and healthy controls. The\n                      <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>\n                      rs2232365 showed no association with\n                      <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\n                      susceptibility and severity and the results of other genetic models were also nonsignificant. On the other hand, rs3761548\n                      <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.003),\n                      <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>\n                      +\n                      <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0014) as well as\n                      <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>\n                      +\n                      <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.40) genotypes showed association with Grade 4 knee\n                      <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\n                      patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our findings indicated that the association between\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">FOXP<\/jats:styled-content>\n                        3\n                      <\/jats:italic>\n                      rs2232365 polymorphism and knee\n                      <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\n                      tended to yield negative results but the\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">FOXP<\/jats:styled-content>\n                        3\n                      <\/jats:italic>\n                      rs3761548 C allele was associated with elevated risk of\n                      <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\n                      in Grade 4 knee\n                      <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\n                      patients in a Turkish population.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.13337","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T03:22:35Z","timestamp":1535685755000},"page":"1779-1786","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["<i>\n                      <scp>FOXP<\/scp>\n                      3\n                    <\/i>\n                    rs3761548 polymorphism is associated with knee osteoarthritis in a Turkish population"],"prefix":"10.1111","volume":"21","author":[{"given":"Nilgun","family":"Cekin","sequence":"first","affiliation":[{"name":"Medicine 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