{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:36:50Z","timestamp":1787240210828,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,8,26]],"date-time":"2018-08-26T00:00:00Z","timestamp":1535241600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      Methotrexate (\n                      <jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content>\n                      ) is the first\u2010line disease\u2010modifying antirheumatic drug in rheumatoid arthritis (\n                      <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\n                      ). However, this anchor may cause some side effects that may range from nausea to mortality. The clinical features of\n                      <jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content>\n                      toxicity are under\u2010researched. In this study, we aimed to find out the potential predisposing factors and outcomes of the\n                      <jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content>\n                      toxicity (\n                      <jats:italic>n\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      31).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The data were collected from 31 patients whose ages ranged from 25 to 81\u00a0years, who were suffering from immune\u2010mediated inflammatory diseases and major\n                      <jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content>\n                      \u2010related toxicity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Out of 31 patients, six (19.4%) used\n                      <jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content>\n                      every day, and 13 (41.9%) patients had renal insufficiency who were admitted to the hospital because of mucositis (90.3%) and fever (71%). While using\n                      <jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content>\n                      , 27 patients (87.1%) were discharged after the treatment and four patients (12.9%) died.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Although\n                      <jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content>\n                      has high efficacy for the toxicity ratio, wrong use and dosage of\n                      <jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content>\n                      may be harmful to patients. Thus, patients should be informed about the proper use of\n                      <jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.13339","type":"journal-article","created":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T19:07:40Z","timestamp":1535569660000},"page":"1557-1562","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Methotrexate intoxication: Beyond the adverse events"],"prefix":"10.1111","volume":"21","author":[{"given":"Ediz","family":"Dalkilic","sequence":"first","affiliation":[{"name":"Division of Rheumatology Faculty of Medicine Uluda\u011f University Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0298-4157","authenticated-orcid":false,"given":"Belk\u0131s 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