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Joinpoint regression was used to assess secular trends in age\u2010standardized hospitalization rates (<jats:styled-content style=\"fixed-case\">ASHR<\/jats:styled-content>) and proportions of <jats:styled-content style=\"fixed-case\">SCTD<\/jats:styled-content> from all and musculoskeletal disorders hospitalizations. We also assessed the secular trends in the absolute and relative regional disparities of <jats:styled-content style=\"fixed-case\">SCTD<\/jats:styled-content> hospitalizations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 89\u00a0333 <jats:styled-content style=\"fixed-case\">SCTD<\/jats:styled-content> hospitalizations (0.3% of all hospitalizations), of these about 69% were for women and 49% of patients were aged 15\u201064\u00a0years. Polyarteritis nodosa and related conditions (<jats:styled-content style=\"fixed-case\">PANRC<\/jats:styled-content>) and systemic lupus erythematosus (<jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>) were the most frequent <jats:styled-content style=\"fixed-case\">SCTD<\/jats:styled-content> among those aged &lt;10\u00a0years and 10\u201054\u00a0years, respectively. Joinpoint regression suggested that both rates and proportions of <jats:styled-content style=\"fixed-case\">SCTD<\/jats:styled-content> hospitalizations declined over time. These trends persisted among sex, age and diagnosis subgroups except for <jats:styled-content style=\"fixed-case\">PANRC<\/jats:styled-content> in patients aged 0\u201019\u00a0years who observed an average annual increase of 3.4% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.8, 5.1) over the study period. There were 2.4\u2010fold (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 2.3\u20102.5) difference between the regions with the highest and lowest mean <jats:styled-content style=\"fixed-case\">ASHR<\/jats:styled-content>. There was no statistically significant secular trend in the relative regional disparities, whereas the absolute regional disparity declined over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There were substantial decreases in the absolute and relative burden of <jats:styled-content style=\"fixed-case\">SCTD<\/jats:styled-content> hospitalizations reflecting possible improvements in disease management in Sweden. The rising trend in <jats:styled-content style=\"fixed-case\">PANRC<\/jats:styled-content> among the youngest children warrants further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13341","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T02:54:30Z","timestamp":1535684070000},"page":"1900-1906","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Hospitalizations due to systemic connective tissue diseases: Secular trends and regional disparities in Sweden, 1998\u20102016"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4254-9099","authenticated-orcid":false,"given":"Aliasghar A.","family":"Kiadaliri","sequence":"first","affiliation":[{"name":"Clinical Epidemiology Unit Department of Clinical Sciences\u2010Lund, Orthopaedics Faculty of Medicine Lund University Lund 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