{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T22:20:16Z","timestamp":1775254816426,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,10,21]],"date-time":"2018-10-21T00:00:00Z","timestamp":1540080000000},"content-version":"vor","delay-in-days":50,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      Antineutrophil cytoplasmic antibody\u2010associated vasculitides (\n                      <jats:styled-content style=\"fixed-case\">AAV<\/jats:styled-content>\n                      ) are a group of small vessel vasculitis with systemic presentations and considerable morbidity and mortality. Pregnancy in these patients poses a significant therapeutic challenge. There is limited published literature regarding pregnancy in\n                      <jats:styled-content style=\"fixed-case\">AAV<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Two cases of successful pregnancy outcomes in patients with active\n                      <jats:styled-content style=\"fixed-case\">AAV<\/jats:styled-content>\n                      are described. A systematic review was conducted on the lines of the\n                      <jats:styled-content style=\"fixed-case\">PRISMA<\/jats:styled-content>\n                      statement for conducting systemic reviews: PubMed (inception of PubMed until 30 April 2017, English language only) and EmBase databases were searched using the following terms: \u2018pregnancy\u2019\n                      <jats:styled-content style=\"fixed-case\">AND<\/jats:styled-content>\n                      \u2018\n                      <jats:styled-content style=\"fixed-case\">ANCA<\/jats:styled-content>\n                      associated vasculitis\u2019\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      \u2018granulomatosis with polyangiitis\u2019\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      \u2018eosinophilic granulomatosis with polyangiitis\u2019\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      \u2018microscopic polyangiitis\u2019\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      \u2018Churg\u2010Strauss syndrome\u2019\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      \u2018Wegener's granulomatosis\u2019.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred and thirty\u2010seven pregnancies were documented in 110 patients of\n                      <jats:styled-content style=\"fixed-case\">AAV<\/jats:styled-content>\n                      . Vasculitis diagnosis was made before pregnancy in 69, during pregnancy in 32 and after pregnancy in 9 patients. Mean age at the time of pregnancy was 29.3\u00a0\u00b1\u00a05.3\u00a0years. There were 91 term pregnancies, 28 were preterm pregnancies, 15 abortions and 3 still births; 78 had normal delivery and 26 had caesarian section.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Successful pregnancies have been reported in\n                      <jats:styled-content style=\"fixed-case\">AAV<\/jats:styled-content>\n                      patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.13342","type":"journal-article","created":{"date-parts":[[2018,10,21]],"date-time":"2018-10-21T20:25:53Z","timestamp":1540153553000},"page":"1734-1740","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Successful treatment outcomes in pregnant patients with\n                    <scp>ANCA<\/scp>\n                    \u2010associated vasculitides: A systematic review of literature"],"prefix":"10.1111","volume":"21","author":[{"given":"Pawan","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aadhaar","family":"Dhooria","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2642-8895","authenticated-orcid":false,"given":"Manish","family":"Rathi","sequence":"additional","affiliation":[{"name":"Department of Nephrology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritesh","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kusum","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Microbiology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3626-0694","authenticated-orcid":false,"given":"Varun","family":"Dhir","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritambhra","family":"Nada","sequence":"additional","affiliation":[{"name":"Department of Histopathology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjana","family":"Minz","sequence":"additional","affiliation":[{"name":"Department of Immunopathology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanita","family":"Suri","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0813-1243","authenticated-orcid":false,"given":"Aman","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209133"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.3656"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq421"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2015-210373"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2015.10.051"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.329"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12454"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-7217-3"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-009-1143-x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.39.985"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)61046-X"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-007-0628-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1997.tb11991.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/33.8.776"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(94)02032-9"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000236543"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.54.7.604"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000237140"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21556"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000327174"},{"key":"e_1_2_8_22_1","first-page":"331","article-title":"Microscopic polyangiitis: an unusual neurologic complication","volume":"22","author":"Kaaroud H","year":"2011","journal-title":"Saudi J Kidney Dis Transpl"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-200295120-00018"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg463"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.01.001"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2010.546807"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1998.tb10243.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100099515"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443610802234368"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.7.1789"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/37.3.331"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.02.016"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61400-7"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400722"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1258\/om.2009.080053"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.09.2009.2296"},{"key":"e_1_2_8_37_1","first-page":"463","article-title":"Wegener's granulomatosis complicated by pregnancy. A case report","volume":"36","author":"Fields CL","year":"1991","journal-title":"J Reprod Med"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270118"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1996.tb02730.x"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.113.3.836"},{"key":"e_1_2_8_41_1","first-page":"1075659","article-title":"Granulomatosis with polyangiitis presenting as Pauci\u2010Immune crescentic glomerulonephritis in pregnancy","volume":"2016","author":"Kunjal R","year":"2016","journal-title":"Case Rep Nephrol"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.03.001"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(04)00986-2"},{"key":"e_1_2_8_44_1","first-page":"S86","article-title":"Wegener's granulomatosis occurring de novo during pregnancy","volume":"27","author":"Alfhaily F","year":"2009","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-004-0932-5"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-008-0020-9"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv060"},{"issue":"1","key":"e_1_2_8_48_1","doi-asserted-by":"crossref","first-page":"i60","DOI":"10.1093\/ndt\/gfu392","article-title":"The long\u2010term outcomes of systemic vasculitis","volume":"30","author":"Westman K","year":"2015","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev018"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21983"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1404231"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909905"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909169"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-295444"},{"key":"e_1_2_8_55_1","first-page":"2331","article-title":"Granulomatosis with polyangiitis in pregnancy \u2010 clinical implications and treatment possibilities","volume":"19","author":"Grygiel\u2010Gorniak B","year":"2015","journal-title":"Eur Rev Med Pharmacol Sci"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.13342","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.13342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T20:58:46Z","timestamp":1775249926000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.13342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":54,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1111\/1756-185X.13342"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.13342","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"2018-10-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}