{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T21:16:14Z","timestamp":1781644574318,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,9,2]],"date-time":"2018-09-02T00:00:00Z","timestamp":1535846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Pain is a serious burden for rheumatoid arthritis (RA<\/jats:styled-content>) patients. However, the effect on Health Assessment Questionnaire Disability Index (HAQ<\/jats:styled-content>\u2010DI<\/jats:styled-content>) and 28\u2010joint Disease Activity Score (DAS<\/jats:styled-content>28) has not been presented. The aim of this study is to evaluate them in a case series.<\/jats:p><\/jats:sec>Methods<\/jats:title>Three hundred and eighty\u2010two RA<\/jats:styled-content> patients who were treated for more than 5\u00a0years were studied. The parameters assessed included average value of the DAS<\/jats:styled-content>28 with C\u2010reactive protein (DAS<\/jats:styled-content>28\u2010CRP<\/jats:styled-content>), the HAQ<\/jats:styled-content>\u2010DI<\/jats:styled-content> score, the Sharp\/van der Heijde Score (SvdHS<\/jats:styled-content>), age, and the pain score measured by a visual analog scale (PS<\/jats:styled-content>\u2010VAS<\/jats:styled-content>). Relationships among these factors and the relationships between the HAQ<\/jats:styled-content>\u2010DI<\/jats:styled-content> score and the other factors, and the relationships between the change in HAQ<\/jats:styled-content>\u2010DI<\/jats:styled-content> scores and the changes in other factors were evaluated statistically with multivariate linear regression analysis. The effect of PS<\/jats:styled-content>\u2010VAS<\/jats:styled-content> on HAQ<\/jats:styled-content>\u2010DI<\/jats:styled-content> was compared with that of DAS<\/jats:styled-content>28\u2010CRP<\/jats:styled-content> on the overlapping data of each parameter.<\/jats:p><\/jats:sec>Results<\/jats:title>HAQ<\/jats:styled-content>\u2010DI<\/jats:styled-content> demonstrated significant positive correlations with all parameters. However, PS<\/jats:styled-content>\u2010VAS<\/jats:styled-content> demonstrated a stronger effect than DAS<\/jats:styled-content>28\u2010CRP<\/jats:styled-content>, also demonstrated without overlapping data. After minimizing the effects of DAS<\/jats:styled-content>28\u2010CRP<\/jats:styled-content>, age and SvdHS<\/jats:styled-content>, there was a significant correlation between HAQ<\/jats:styled-content>\u2010DI<\/jats:styled-content> and PS<\/jats:styled-content>\u2010VAS<\/jats:styled-content> in all analyses. The change in HAQ<\/jats:styled-content>\u2010DI<\/jats:styled-content> demonstrated a significant correlation with the change in PS<\/jats:styled-content>\u2010VAS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>These results suggested that HAQ<\/jats:styled-content>\u2010DI<\/jats:styled-content> is deeply influenced by PS<\/jats:styled-content>\u2010VAS<\/jats:styled-content>. The effect of DAS<\/jats:styled-content>28\u2010CRP<\/jats:styled-content> overlapped with the effect of PS<\/jats:styled-content>\u2010VAS<\/jats:styled-content> in a major way. Pain control for RA<\/jats:styled-content> patients is the most important factor contributing to activities of daily living, as well as disease activity control.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13351","type":"journal-article","created":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T05:24:28Z","timestamp":1535952268000},"page":"1955-1961","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Influence of pain score measured by a visual analog scale (PS<\/scp>\u2010VAS<\/scp>) on the Health Assessment Questionnaire Disability Index and 28\u2010joint Disease Activity Index with C\u2010reactive protein in rheumatoid arthritis patients"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9123-4624","authenticated-orcid":false,"given":"Ichiro","family":"Yoshii","sequence":"first","affiliation":[{"name":"Department of Rheumatology Yoshii Hospital Shimanto City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsumi","family":"Chijiwa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Kochi Memorial Hospitals Kochi City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Sawada","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Dohgo Onsen Hospital Matsuyama City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/25.2.206"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-205079"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20048"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199804093381506"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.114652"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23255"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780300605"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.123919"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207524"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1740"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)92442-2"},{"key":"e_1_2_5_14_1","first-page":"211","volume-title":"Pain and Disability: clinical, Behavioral, and Public Policy Perspectives","author":"Institute of Medicine (US) Committee on Pain, Disability, and Chronic Illness Behavior","year":"1987"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.138693"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-199309000-00004"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.009530"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201519"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34543"},{"key":"e_1_2_5_20_1","first-page":"1","article-title":"Determinants of Patient's Global Assessment of Disease Activity and Physician's Global Assessment of Disease Activity in patients with rheumatoid arthritis: a post hoc analysis of overall and Japanese results from phase 3 clinical trials","author":"Kaneko Y","year":"2017","journal-title":"Mod Rheumatol"},{"key":"e_1_2_5_21_1","first-page":"1","article-title":"Relationship between disease activity and patient\u2010reported outcomes in rheumatoid arthritis: post hoc analyses of overall and Japanese results from two phase 3 clinical trials","author":"Ishiguro N","year":"2017","journal-title":"Mod Rheumatol"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-016-3641-x"},{"key":"e_1_2_5_23_1","first-page":"1","article-title":"Relationship between achievement of physical activity goal and characteristics of patients with rheumatoid arthritis","author":"Mochizuki T","year":"2017","journal-title":"Mod Rheumatol"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.030924"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.13351","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.13351","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.13351","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.13351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T02:39:17Z","timestamp":1694313557000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.13351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,2]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1111\/1756-185X.13351"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.13351","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,2]]},"assertion":[{"value":"2017-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}