{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T23:43:11Z","timestamp":1769125391106,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,8,26]],"date-time":"2018-08-26T00:00:00Z","timestamp":1535241600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the frequency and define the causes of pulmonary hypertension (<jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>) in patients with Takayasu arteritis (<jats:styled-content style=\"fixed-case\">TA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Sixty\u2010four <jats:styled-content style=\"fixed-case\">TA<\/jats:styled-content> patients were evaluated by transthoracic echocardiography (<jats:styled-content style=\"fixed-case\">TTE<\/jats:styled-content>). Having an estimated systolic pulmonary arterial pressure (<jats:styled-content style=\"fixed-case\">sPAP<\/jats:styled-content>) \u226540\u00a0mm\u00a0Hg by echocardiography or if performed, mean <jats:styled-content style=\"fixed-case\">PAP<\/jats:styled-content> \u226525\u00a0mm\u00a0Hg in right heart catheterization was defined as <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>. Clinical, imaging and laboratory results of the <jats:styled-content style=\"fixed-case\">TA<\/jats:styled-content> patients were obtained from hospital files.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>In total, seven (10.9%) patients had <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>. Four patients had <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content> due to left\u2010sided heart disease (group 2 <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>), three patients due to pulmonary arterial involvement (<jats:styled-content style=\"fixed-case\">PAI<\/jats:styled-content>; group 4 <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>) and one patient due to atrial septal defect (group\u00a01 <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>). In one patient, combination of PAI, aortic insufficiency and pulmonary venous return anomaly was present and he was considered to have both group 2 and group 4 <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">PAI<\/jats:styled-content> was more frequent (42.9% vs 15.7%) in patients with <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content> but the difference was not statistically significant. The percentage of patients treated with cyclophosphamide and\/or biologics was higher in the group with <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content> as compared to the group without <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.015). One patient with group 4 <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content> had been on pulmonary arterial hypertension (<jats:styled-content style=\"fixed-case\">PAH<\/jats:styled-content>)\u2010specific agents for 8\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pulmonary hypertension is not infrequent in <jats:styled-content style=\"fixed-case\">TA<\/jats:styled-content> patients and all the potential causes of <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content> should be carefully evaluated. Patients with severe or treatment\u2010resistant disease are prone to have <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">PAH<\/jats:styled-content>\u2010specific agents may be effective in patients with group 4 <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13354","type":"journal-article","created":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T23:07:40Z","timestamp":1535584060000},"page":"1634-1639","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Pulmonary hypertension in Takayasu arteritis"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3286-0940","authenticated-orcid":false,"given":"Alper","family":"Sari","sequence":"first","affiliation":[{"name":"Department of Rheumatology Faculty of Medicine Hacettepe University Ankara 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