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Novel open\u2010ended approaches like large\u2010scale genotyping, proteomics and metabolomics have helped gain novel insights into <jats:styled-content style=\"fixed-case\">TA<\/jats:styled-content>, giant cell arteritis (<jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content>) and anti\u2010neutrophil cytoplasmic antibody\u2010associated vasculitis (<jats:styled-content style=\"fixed-case\">AAV<\/jats:styled-content>). Recent advances in the imaging of <jats:styled-content style=\"fixed-case\">TA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content> offer promise for earlier diagnosis and better monitoring of response to therapy. Although two randomized controlled trials of abatacept and tocilizumab failed to meet their primary end\u2010points, successful large\u2010scale studies of abatacept and tocilizumab in <jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content> hold promise for better disease control. While cyclophosphamide has revolutionized the management of <jats:styled-content style=\"fixed-case\">AAV<\/jats:styled-content>, increasing use of rituximab as an alternative induction regimen, as well as use of novel approaches involving reduced or no corticosteroid use for <jats:styled-content style=\"fixed-case\">AAV<\/jats:styled-content> and alternative agents such as avacopan (a complement 5a receptor antagonist) hold promise for lesser toxic induction regimens in the future. Increasingly, the risk of cardiovascular events and comorbidities such as osteoporosis are being recognized as factors affecting long\u2010term prospects of patients with vasculitis. There is a shift in emphasis to utilize patient\u2010reported outcomes to more accurately gauge the impact of vasculitides and their treatment.<\/jats:p>","DOI":"10.1111\/1756-185x.13370","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T02:23:57Z","timestamp":1535682237000},"page":"10-20","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Vasculitis research: Current trends and future perspectives"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5035-7396","authenticated-orcid":false,"given":"Durga P.","family":"Misra","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS) Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Godasi S. R. S. N. 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