{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:23:25Z","timestamp":1793391805905,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T00:00:00Z","timestamp":1535587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Tuberculosis (<jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>) is one of the major adverse events of concern associated with the use of biologics for managing autoimmune inflammatory rheumatic diseases (<jats:styled-content style=\"fixed-case\">AIRD<\/jats:styled-content>s). The study presents the data on incidence of <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> in relation to biologic used, screening test and <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> prophylaxis in a real\u2010world setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The cross\u2010sectional, observational, retrospective study was conducted across 12 centres in Karnataka, India. The study included patients receiving biologics therapy for <jats:styled-content style=\"fixed-case\">AIRD<\/jats:styled-content>s, established based on the respective diagnostic criteria. The development of <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> after receiving biologic therapy and other clinical variables and the predictability of the test performed for latent <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and ninety\u2010five <jats:styled-content style=\"fixed-case\">AIRD<\/jats:styled-content>s patients with an average age of 41 years were initiated on biologic therapy. Twenty\u2010one patients were latent <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> positive and were given antitubercular prophylaxis, prior to biologics treatment. During follow\u2010up, seven patients belonging to the negative test group (n = 174) developed <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>. The negative predictive values noted for Mantoux test (n = 120) and quanti<jats:styled-content style=\"fixed-case\">FERON TB<\/jats:styled-content> gold test (n = 178) were 96.52% and 96.25%, respectively. Patients on anti\u2010tumor necrosis factor were more likely to develop <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>. Presence of comorbidities and steroid use increased the likelihood of developing <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> by 1.5 and 4.6 times, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Close monitoring of patients receiving biologics is essential for early identification of adverse events, especially in test negative patients. Prophylaxis can effectively reduce the risk of developing <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> in patients positive for screening.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13376","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T07:24:58Z","timestamp":1535700298000},"page":"280-287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Biologics and risk of tuberculosis in autoimmune rheumatic diseases: A real\u2010world clinical experience from India"],"prefix":"10.1111","volume":"22","author":[{"given":"Vineeta","family":"Shobha","sequence":"first","affiliation":[{"name":"St. John's Medical College Hospital Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2661-9840","authenticated-orcid":false,"given":"S.","family":"Chandrashekara","sequence":"additional","affiliation":[{"name":"ChanRe Rheumatology and Immunology Center and Research Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Rao","sequence":"additional","affiliation":[{"name":"Manipal Hospital Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9525-3435","authenticated-orcid":false,"given":"Anu","family":"Desai","sequence":"additional","affiliation":[{"name":"St. John's Medical College Hospital Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Jois","sequence":"additional","affiliation":[{"name":"Fortis Hospital Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balebail G.","family":"Dharmanand","sequence":"additional","affiliation":[{"name":"SAKRA Hospital Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharath","family":"Kumar","sequence":"additional","affiliation":[{"name":"Columbia Asia Hospital Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Kumar","sequence":"additional","affiliation":[{"name":"Apollo Hospital Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chethana","family":"Dharmapalaiah","sequence":"additional","affiliation":[{"name":"Apollo Hospital Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurugodu Mathada","family":"Mahendranath","sequence":"additional","affiliation":[{"name":"Samarpan Health Centre Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiva","family":"Prasad","sequence":"additional","affiliation":[{"name":"Vikram Hospital and Heart Care Mysore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manisha Ashwin","family":"Daware","sequence":"additional","affiliation":[{"name":"Narayana Health City Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogesh","family":"Singh","sequence":"additional","affiliation":[{"name":"Manipal Hospital Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma","family":"Karjigi","sequence":"additional","affiliation":[{"name":"Apollo Hospital Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Nagaraj","sequence":"additional","affiliation":[{"name":"Columbia Asia Hospital Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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