{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T02:43:33Z","timestamp":1779245013325,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T00:00:00Z","timestamp":1535587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Abstract Rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>) is a chronic, inflammatory disease closely linked with atherosclerosis. Recommended cardiovascular disease (<jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>) integral evaluation includes screening for asymptomatic atherosclerosis plaques with carotid ultrasound (<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>). The aim of this study is to evaluate the carotid <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> characteristics, including carotid intima media thickness (<jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content>) and carotid plaque (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>), and compare <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\u2010patients and controls in a Mexican\u2010mestizo population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Prospective cross\u2010sectional, observational study comparing <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\u2010patients and matched controls without <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>. Medical history and physical exam was performed in all subjects by a rheumatologist and two clinical blinded radiologists did the carotid <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>. Increased <jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content> was defined as \u22650.9\u00a0mm. <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> was defined as a focal narrowing \u22650.5\u00a0mm of the surrounding lumen or a <jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content> \u22651.2\u00a0mm. Multivariable analysis was done comparing <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\u2010patients and control subjects characteristics with carotid US.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>In the final analysis 209 patients were included, 103 patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> and 106 controls. Bilateral <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> was found more than twice in <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> than controls (15.5% vs 6.6%). Unilateral <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> was more common in either side evaluated, being heterogeneous plaques the most common in <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\u2010patients. The prevalence of increased <jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content> was found higher in <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\u2010patients either in both sides (right 37.9% vs 15.1%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.00; left 43.7% vs 19.8%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.00) were statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It was confirmed that <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\u2010patients have greater subclinical atherosclerosis represented in the carotid <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> measuring <jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> as surrogates. <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\u2010patients with subclinical atherosclerotic disease have more heterogeneous plaques characteristics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13377","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T03:18:47Z","timestamp":1535685527000},"page":"25-31","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Carotid ultrasound findings in rheumatoid arthritis and control subjects: A case\u2010control study"],"prefix":"10.1111","volume":"22","author":[{"given":"Martin I.","family":"Wah\u2010Suarez","sequence":"first","affiliation":[{"name":"Internal Medicine Department University Hospital Dr.Jose Eleuterio Gonzalez UANL Monterrey Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dionicio A.","family":"Galarza\u2010Delgado","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Rheumatology Division University Hospital Dr. Jose Eleuterio Gonzalez UANL Monterrey Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose R.","family":"Azpiri\u2010Lopez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Cardiology Division University Hospital Dr. Jose Eleuterio Gonzalez UANL Monterrey Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris J.","family":"Colunga\u2010Pedraza","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Rheumatology Division University Hospital Dr. Jose Eleuterio Gonzalez UANL Monterrey Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2766-095X","authenticated-orcid":false,"given":"Estefania E.","family":"Abundis\u2010Marquez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Rheumatology Division University Hospital Dr. Jose Eleuterio Gonzalez UANL Monterrey Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose A.","family":"Davila\u2010Jimenez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Cardiology Division University Hospital Dr. Jose Eleuterio Gonzalez UANL Monterrey Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinthia Y.","family":"Guillen\u2010Gutierrez","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging University Hospital Dr. Jose Eleuterio Gonzalez UANL Monterrey Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Elizondo\u2010Riojas","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging University Hospital Dr. Jose Eleuterio Gonzalez UANL Monterrey Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-205058"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000054612.26458.B2"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.143396"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200726"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209775"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-203101"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203688"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.110.959403"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph121114275"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30265"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.08.129"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr399"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002377"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2008.01.012"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-S005"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr158"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328364ca4c"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2007.02.004"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2007.11.011"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2013.11.014"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24014"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.4.841"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2006.102848"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.recesp.2010.06.007"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJR.0b013e3283312ece"},{"key":"e_1_2_5_27_1","unstructured":"DaviglusML TalaveraGA AvileML et\u00a0al.Prevalence of Major Cardiovascular Risk Factors and Cardiovascular Diseases Among Hispanic\/Latino Individuals of Diverse Backgrounds in the United States.2015."},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2010.06.006"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000101572.76273.60"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2016.07.026"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12947-015-0041-4"},{"issue":"7","key":"e_1_2_5_32_1","first-page":"1219","article-title":"High\u2010grade C\u2010reactive protein elevation correlates with accelerated atherogenesis in patients with rheumatoid arthritis","volume":"32","author":"Gonzalez\u2010Gay MA","year":"2005","journal-title":"J Rheumatol"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22482"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0576-7"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-015-2996-9"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21288"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-016-3536-y"},{"key":"e_1_2_5_38_1","first-page":"492","article-title":"Ultrasonographic risk score of carotid plaques","volume":"498","author":"Pedro LM\u00c3","year":"2002","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7120-4-16"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1159\/000437339"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120621"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206411"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.150510"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-015-0767-x"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209744"},{"key":"e_1_2_5_46_1","first-page":"1","article-title":"Metabolic syndrome and subclinical carotid damage: a meta\u2010analysis from population\u2010based studies","volume":"35","author":"Cuspidia C","year":"2017","journal-title":"J Hypertens"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.11.006"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.13377","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.13377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T07:55:15Z","timestamp":1694678115000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.13377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,30]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/1756-185X.13377"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.13377","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,30]]},"assertion":[{"value":"2018-02-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}