{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:58:49Z","timestamp":1778745529262,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,12,16]],"date-time":"2018-12-16T00:00:00Z","timestamp":1544918400000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Allergy inhibitory receptor\u20101 (Allergin\u20101) is a newly identified immune regulatory molecule thought to influence autoantibody production. Autoantibody production, like that observed in Allergin\u20101\u2010deficient mice, is crucial in the pathogenesis of several autoimmune diseases such as systemic lupus erythematosus. The purpose of this study is to clarify the regulatory role of Allergin\u20101\u2010mediated autoantibody production using a murine model of thymocytic anaphylaxis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>C57BL\/6 (WT) and Allergin\u20101\u2010deficient mice were treated with apoptotic cells from naive thymocytes stimulated by dexamethasone. Antibody titers of total or immunoglobulin G (IgG) subclass of anti\u2010double\u2010stranded DNA (anti\u2010dsDNA) and anti\u2010histone antibody from serum were measured using an enzyme\u2010linked immunosorbent assay. Macrophages from wild\u2010type (WT) or Allergin\u20101\u2010deficient mice were co\u2010cultured with fluorescence\u2010labeled apoptotic thymocytes or fluorogenic reagent and resultant phagocytic activity was quantified by with flow cytometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After apoptotic cells injection, antibody titers of total and IgG3 anti\u2010dsDNA and total anti\u2010histone from serum were significantly increased in Allergin\u20101\u2010deficient versus WT mice. Phagocytic activity was significantly lower in macrophages from Allergin\u20101\u2010deficient mice versus WT mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Allergin\u20101 might play an inhibitory role in autoantibody production via upregulation of macrophage phagocytosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13381","type":"journal-article","created":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T07:58:34Z","timestamp":1545033514000},"page":"2071-2078","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Allergy inhibitory receptor\u20101 inhibits autoantibody production via upregulation of apoptotic debris clearance by macrophages"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2545-5138","authenticated-orcid":false,"given":"Akira","family":"Iizuka","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Faculty of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Segawa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Faculty of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuya","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Faculty of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunta","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Faculty of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Yokosawa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Faculty of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotona","family":"Furuyama","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Faculty of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruka","family":"Miki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Faculty of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoko","family":"Tahara\u2010Hanaoka","sequence":"additional","affiliation":[{"name":"Department of Immunology Faculty of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Department of Immunology Faculty of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Tsuboi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Faculty of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Faculty of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Faculty of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Shibayama","sequence":"additional","affiliation":[{"name":"Research Center of Immunology ONO Pharmaceutical Co. 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