{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:41:04Z","timestamp":1791942064856,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T00:00:00Z","timestamp":1535587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2019,1]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>To investigate whether remission can be sustained for rheumatoid arthritis (RA<\/jats:styled-content>) patients after tapering abatacept (ABT<\/jats:styled-content>).<\/jats:p><\/jats:sec>Method<\/jats:title>All patients were na\u00efve to biological disease\u2010modifying anti\u2010rheumatic drugs (bDMARD<\/jats:styled-content>s) and in low or moderate Disease Activity Score of 28 joints with C\u2010reactive protein (DAS<\/jats:styled-content>)28\u2010CRP<\/jats:styled-content>).ABT<\/jats:styled-content>was administrated intravenously (IV<\/jats:styled-content>) or subcutaneously (SC<\/jats:styled-content>) for 36\u00a0weeks to patients withRA<\/jats:styled-content>, who had not previously receivedbDMARD<\/jats:styled-content>s. As theABT<\/jats:styled-content>tapering protocol,ABT<\/jats:styled-content>was administratedSC<\/jats:styled-content>at 125\u00a0mg every 2\u00a0weeks for 12\u00a0weeks in patients with remission.RA<\/jats:styled-content>disease activity was assessed byDAS<\/jats:styled-content>28\u2010CRP<\/jats:styled-content>and ultrasonography. Remission was assessed by defining it asDAS<\/jats:styled-content>28\u2010CRP<\/jats:styled-content><2.3.<\/jats:p><\/jats:sec>Results<\/jats:title>Of the 51 patients, 84.3% were women (mean age 68.7\u00a0\u00b1\u00a010.2\u00a0years, mean disease duration 7.7\u00a0\u00b1\u00a010.2\u00a0years). Twenty\u2010nine patients achieved remission and a power Doppler (PD<\/jats:styled-content>) score \u22641 at each joint at 36\u00a0weeks, followed by taperingABT<\/jats:styled-content>. Of these patients, 25 sustainedDAS<\/jats:styled-content>28\u2010CRP<\/jats:styled-content>remission, andDAS<\/jats:styled-content>28\u2010CRP<\/jats:styled-content>was not significantly elevated (1.62\u00a0\u00b1\u00a00.41 to 1.69\u00a0\u00b1\u00a00.49) at 48\u00a0weeks, but the totalPD<\/jats:styled-content>score was significantly elevated (1.52\u00a0\u00b1\u00a01.21 to 2.59\u00a0\u00b1\u00a02.81P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.049). Longer disease duration, higherDAS<\/jats:styled-content>28\u2010CRP<\/jats:styled-content>at 24\u00a0weeks, and higher totalPD<\/jats:styled-content>score at 24\u00a0weeks were predictors of an elevated totalPD<\/jats:styled-content>score after taperingABT<\/jats:styled-content>therapy.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>These findings suggest thatABT<\/jats:styled-content>tapering is a promising short\u2010term strategy to sustain remission in patients withRA<\/jats:styled-content>, and ultrasonography is a useful tool for monitoring disease activity after taperingABT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13384","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T04:58:47Z","timestamp":1535691527000},"page":"81-89","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy of abatacept tapering therapy for sustained remission in 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