{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:10:02Z","timestamp":1790122202213,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T00:00:00Z","timestamp":1536105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the impact of an aerobic fitness program on disease activity, defined by the Bath Ankylosing Spondylitis Disease Activity Index (<jats:styled-content style=\"fixed-case\">BASDAI<\/jats:styled-content>) and on C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>), erythrocyte sedimentation rate (<jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content>) and the Bath Ankylosing Spondylitis Functional Index (<jats:styled-content style=\"fixed-case\">BASFI<\/jats:styled-content>) in case of axial spondyloarthritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review of the literature, following the Prisma recommendations, was performed by two reviewers on the PubMed and Embase databases. Controlled trials assessing the efficacy of aerobic exercises compared to physiotherapy on axial spondyloarthritis disease activity were included. The diagnosis of axial spondyloarthritis was meeting the New York criteria and\/or the Assessment in Axial Spondyloarthritis International Working Group criteria. Aerobic fitness was defined as an exercise performed at 50%\u201090% of the maximal heart rate or between 50% and 80% oxygen consumption (<jats:styled-content style=\"fixed-case\">VO<\/jats:styled-content><jats:sub>2<\/jats:sub>) peak.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five hundred and twenty abstracts were identified and 93 abstracts were analyzed. Eight studies met the selection criteria and 6 were finally included in this study because of the presence of a control group. Both groups were similar in terms of age, sex ratio, disease duration. Aerobic exercise provided a positive impact on the <jats:styled-content style=\"fixed-case\">BASDAI<\/jats:styled-content> in the intervention group (148 patients) (weighted mean difference [<jats:styled-content style=\"fixed-case\">WMD<\/jats:styled-content>]: \u22120.52 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: \u22120.9 to \u22120.13]) (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>: 10.3%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.35). However, when compared to a control group (152 patients), the improvement of <jats:styled-content style=\"fixed-case\">BASDAI<\/jats:styled-content> didn't reach significance (<jats:styled-content style=\"fixed-case\">WMD<\/jats:styled-content>: \u22120.25 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: \u22120.83 to 0.32]) (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>: 0%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.41). Aerobic exercise did not improve <jats:styled-content style=\"fixed-case\">BASFI<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CRP<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Aerobic exercise did not provide beneficial effects either on disease activity or on physical function and biological parameters when compared to a control group in axial spondyloarthritis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13385","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T01:48:40Z","timestamp":1536198520000},"page":"234-241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Aerobic exercise for axial spondyloarthritis \u2010 its effects on disease activity and function as compared to standard physiotherapy: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2708-2918","authenticated-orcid":false,"given":"Frank","family":"Verhoeven","sequence":"first","affiliation":[{"name":"Department of Rheumatology CHRU Besan\u00e7on Besan\u00e7on France"},{"name":"EA 4267 \u201cPEPITE\u201d, FHU Increase Universit\u00e9 Bourgogne\u2010Franche Comte, UFR SMP Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Guillot","sequence":"additional","affiliation":[{"name":"Department of Rheumatology CHRU Besan\u00e7on Besan\u00e7on France"},{"name":"EA 4267 \u201cPEPITE\u201d, FHU Increase Universit\u00e9 Bourgogne\u2010Franche Comte, UFR SMP Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment","family":"Prati","sequence":"additional","affiliation":[{"name":"Department of Rheumatology CHRU Besan\u00e7on Besan\u00e7on France"},{"name":"EA 4267 \u201cPEPITE\u201d, FHU Increase Universit\u00e9 Bourgogne\u2010Franche Comte, UFR SMP Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Mougin","sequence":"additional","affiliation":[{"name":"EA 3920 EPSI Universit\u00e9 Bourgogne\u2010Franche Comt\u00e9 Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Tordi","sequence":"additional","affiliation":[{"name":"EA 4267 \u201cPEPITE\u201d, FHU Increase Universit\u00e9 Bourgogne\u2010Franche Comte, UFR SMP Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Demougeot","sequence":"additional","affiliation":[{"name":"EA 4267 \u201cPEPITE\u201d, FHU Increase Universit\u00e9 Bourgogne\u2010Franche Comte, UFR SMP Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Wendling","sequence":"additional","affiliation":[{"name":"Department of Rheumatology CHRU Besan\u00e7on Besan\u00e7on France"},{"name":"EA 4266 Universit\u00e9 Bourgogne\u2010Franche Comte UFR SMP Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60635-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.151027"},{"issue":"1","key":"e_1_2_7_4_1","first-page":"CD002822","article-title":"Physiotherapy interventions for ankylosing spondylitis","author":"Dagfinrud H","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2014.10.007"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2015.10.002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205180"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.2.167"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21780"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.150015"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.108233"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(95)00134-4"},{"key":"e_1_2_7_15_1","first-page":"2304","article-title":"Method guidelines for Cochrane Musculoskeletal Group systematic reviews","volume":"33","author":"Maxwell L","year":"2006","journal-title":"J Rheumatol"},{"key":"e_1_2_7_16_1","first-page":"449","article-title":"Are swimming or aerobic exercise better than conventional exercise in ankylosing spondylitis patients? A randomized controlled study","volume":"45","author":"Karapolat H","year":"2009","journal-title":"Eur J Phys Rehabil Med"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-010-1533-0"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22062"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108688"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/398190"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.150518"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-007-0559-4"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-6-185"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e318213fefb"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.160942"},{"key":"e_1_2_7_26_1","first-page":"2286","article-title":"A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index","volume":"21","author":"Garrett S","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.094870"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.100826"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20415"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203643"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2014.10.009"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3772"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.015826"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21165"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20146"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.13385","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.13385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T17:07:27Z","timestamp":1694711247000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.13385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,5]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1111\/1756-185X.13385"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.13385","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,5]]},"assertion":[{"value":"2017-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}