{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:20:44Z","timestamp":1789039244417,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T00:00:00Z","timestamp":1539820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The incidence and clinical features of antineutrophil cytoplasmic antibody (\n                    <jats:styled-content style=\"fixed-case\">ANCA<\/jats:styled-content>\n                    ) associated vasculitis (\n                    <jats:styled-content style=\"fixed-case\">AAV<\/jats:styled-content>\n                    ) have been shown to vary according to geographical areas, with granulomatosis with polyangiitis (\n                    <jats:styled-content style=\"fixed-case\">GPA<\/jats:styled-content>\n                    ) being more common in northern Europe and microscopic polyangiitis (\n                    <jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content>\n                    ) being more common in Asian countries. The annual incidence of\n                    <jats:styled-content style=\"fixed-case\">GPA<\/jats:styled-content>\n                    among Asians varies between 0.37\/million to 2.1\/million population. The prevalence of\n                    <jats:styled-content style=\"fixed-case\">GPA<\/jats:styled-content>\n                    has been estimated to be 1.94\/100\u00a0000 in a Chinese population. Polymorphisms in class\n                    <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n                    major histocompatibility genes and\n                    <jats:styled-content style=\"fixed-case\">ETS<\/jats:styled-content>\n                    1 proto\u2010oncogene has been shown in Asian patients with\n                    <jats:styled-content style=\"fixed-case\">GPA<\/jats:styled-content>\n                    . There is a difference in mean age at onset and proteinase 3 (\n                    <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>\n                    3) or myeloperoxidase (\n                    <jats:styled-content style=\"fixed-case\">MPO<\/jats:styled-content>\n                    ) positivity in\n                    <jats:styled-content style=\"fixed-case\">GPA<\/jats:styled-content>\n                    patients from different Asian countries. Those from India had mean age of 40\u00a0years and those from Japan had mean age of 65\u00a0years. Sixty percent of\n                    <jats:styled-content style=\"fixed-case\">GPA<\/jats:styled-content>\n                    patients from China and Japan were\n                    <jats:styled-content style=\"fixed-case\">MPO ANCA<\/jats:styled-content>\n                    positive while the majority of patients from India and Korea were\n                    <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>\n                    3 positive. Geographical variation with lower frequency of renal involvement in Indian studies and higher frequency in Chinese patients has also been noted. Treatment outcomes have been similar to those reported from other parts of the world. Remission was achieved in about two\u2010thirds of patients while relapses were noted in one\u2010third to half of the patients. Apart from minor differences in the organ systems involved,\n                    <jats:styled-content style=\"fixed-case\">MPO<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">ANCA GPA<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>\n                    3\u2010\n                    <jats:styled-content style=\"fixed-case\">ANCA GPA<\/jats:styled-content>\n                    had similar rates of remission and relapses.\n                  <\/jats:p>","DOI":"10.1111\/1756-185x.13398","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T22:54:03Z","timestamp":1539903243000},"page":"90-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Is granulomatosis with polyangiitis in Asia different from the West?"],"prefix":"10.1111","volume":"22","author":[{"given":"Godasi S. 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