{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:55:32Z","timestamp":1791633332345,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T00:00:00Z","timestamp":1539820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Neutrophil\u2010to\u2010lymphocyte ratio (\n NLR<\/jats:styled-content>\n ) and platelet\u2010to\u2010lymphocyte ratio (\n PLR<\/jats:styled-content>\n ) may be used as indicators of inflammatory markers and disease activity due to inflammatory changes in neutrophils, platelets and lymphocytes. Our aim is to investigate the relationship between\n NLR<\/jats:styled-content>\n ,\n PLR<\/jats:styled-content>\n ratio and disease activity in\n RA<\/jats:styled-content>\n patients treated with rituximab.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Thirty\u2010eight patients (8 male, 30 female, mean age 56.8\u00a0\u00b1\u00a011.8\u00a0years) diagnosed with\n RA<\/jats:styled-content>\n and 30 healthy controls were included in the study. Disease Activity Score of 28 joints \u2010 erythrocyte sedimentation rate (\n DAS<\/jats:styled-content>\n 28\u2010\n ESR<\/jats:styled-content>\n ), lymphocyte, neutrophil, platelet counts,\n ESR<\/jats:styled-content>\n , C\u2010reactive protein (\n CRP<\/jats:styled-content>\n ),\n PLR<\/jats:styled-content>\n , and\n NLR<\/jats:styled-content>\n were evaluated before and after rituximab in\n RA<\/jats:styled-content>\n patients. The relationship between all parameters was assessed by Pearson's correlation, Wilcoxon signed\u2010rank, Mann\u2010Whitney\n U<\/jats:italic>\n and paired\n t<\/jats:italic>\n tests.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The levels of\n CRP<\/jats:styled-content>\n ,\n ESR<\/jats:styled-content>\n , and\n DAS<\/jats:styled-content>\n 28\u2010\n ESR<\/jats:styled-content>\n decreased significantly at 6\u00a0months of rituximab treatment compared to pre\u2010treatment.\n NLR<\/jats:styled-content>\n and\n PLR<\/jats:styled-content>\n ratios were higher in patients with\n RA<\/jats:styled-content>\n than the control group. The median levels were 33.5\u00a0mm\/hour, 5.7\u00a0mg\/\n dL<\/jats:styled-content>\n , and 3.7 respectively after 6\u00a0months of rituximab treatment. And, the levels were lower than baseline treatment. There was a significant correlation between the levels of\n DAS<\/jats:styled-content>\n 28\u2010\n ESR<\/jats:styled-content>\n and\n NLR<\/jats:styled-content>\n ,\n DAS<\/jats:styled-content>\n 28\u2010\n ESR<\/jats:styled-content>\n and\n PLR<\/jats:styled-content>\n before and after treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The\n NLR<\/jats:styled-content>\n and\n PLR<\/jats:styled-content>\n were higher than healthy controls and correlated with\n DAS<\/jats:styled-content>\n 28\u2010\n ESR<\/jats:styled-content>\n in patients with\n RA<\/jats:styled-content>\n . These parameters which are indicative of disease activity decrease with rituximab and correlate with disease activity at 6\u00a0months. The\n NLR<\/jats:styled-content>\n and\n PLR<\/jats:styled-content>\n may be useful indices to evaluate\n RA<\/jats:styled-content>\n disease activity treated with rituximab.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1756-185x.13400","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T22:43:23Z","timestamp":1539902603000},"page":"2122-2127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Relationship between neutrophil\u2010lymphocyte, platelet\u2010lymphocyte ratio and disease activity in rheumatoid arthritis treated with rituximab"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3778-8351","authenticated-orcid":false,"given":"Gokhan","family":"Sargin","sequence":"first","affiliation":[{"name":"Department of Rheumatology Adnan Menderes University Medical Faculty Ayd\u0131n Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taskin","family":"Senturk","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Adnan Menderes University Medical Faculty Ayd\u0131n Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irfan","family":"Yavasoglu","sequence":"additional","affiliation":[{"name":"Department of Hematology Adnan Menderes University Medical Faculty Ayd\u0131n Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reyhan","family":"Kose","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Adnan Menderes University Medical Faculty Ayd\u0131n Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60826-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/15680266113139990092"},{"key":"e_1_2_6_4_1","first-page":"1774","article-title":"The assessment and prediction of functional disability in rheumatoid arthritis","volume":"18","author":"Wolfe F","year":"1991","journal-title":"J Rheumatol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22783"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21641"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21649"},{"key":"e_1_2_6_8_1","first-page":"1477","article-title":"Comparative usefulness of C\u2010reactive protein and erythrocyte sedimentation rate in patients with rheumatoid arthritis","volume":"24","author":"Wolfe F","year":"1997","journal-title":"J Rheumatol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0975-7406.76489"},{"key":"e_1_2_6_10_1","first-page":"1376","article-title":"Acute\u2010phase proteins and other systemic responses to inflammation. 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