{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:53:57Z","timestamp":1792000437645,"version":"4.4.0"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,11,11]],"date-time":"2018-11-11T00:00:00Z","timestamp":1541894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to evaluate the relationship between mean platelet volume (MPV), neutrophil\u2010to\u2010lymphocyte ratio (NLR), platelet\u2010to\u2010lymphocyte ratio (PLR), and Beh\u00e7et\u2019s disease (BD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched Medline, Embase, and Cochrane databases, and performed a meta\u2010analysis to compare MPV, NLR, and PLR between patients with BD and healthy controls, and to evaluate these parameters in BD according to disease activity and thrombosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 14 studies were included. MPV was not higher in the BD group than in the control group (standardized mean difference [SMD], 0163; 95% confidence interval [CI], \u22120.125 to 0.451; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.268), while NLR was significantly higher in the BD group than in the control group (SMD, 1.176; 95% CI, 0.392\u20101.960, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003) and PLR showed a non\u2010significant trend of association with BD (SMD, 0.441; 95% CI, \u22120.025 to 0.907, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.063). MPV did not differ between patients with active and inactive BD (SMD, \u22120.129; 95% CI, \u22120.323 to 0.085, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.191), and between patients with BD with and without thrombosis (SMD, 0.231; 95% CI, \u22120.155 to 0.617, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.241). Conversely, NLR was significantly higher in patients with active BD than in those with inactive BD (SMD, 1.774; 95% CI, 0.179\u20103.368, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.029), but not significantly higher in patients with BD with thrombosis than in those without thrombosis (SMD, 0.258; 95% CI, \u22120.277 to 0.792, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.345).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This finding suggests that NLR may be a potential index to evaluate the disease activity of BD, although there are limitations of small number of studies and heterogeneity of individual characteristics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13404","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T05:38:53Z","timestamp":1542001133000},"page":"2180-2187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Neutrophil\u2010to\u2010lymphocyte ratio, mean platelet volume and platelet\u2010to\u2010lymphocyte ratio in Beh\u00e7et\u2019s disease and their correlation with disease activity: A meta\u2010analysis"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4213-1909","authenticated-orcid":false,"given":"Young Ho","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center Korea University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwan 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