{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:56:54Z","timestamp":1793642214663,"version":"4.5.1"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T00:00:00Z","timestamp":1541376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Anti\u2010transcriptional intermediary factor 1 (TIF1) antibody is associated with idiopathic inflammatory myopathies (IIMs). The aim of this study was to investigate the expression of TIF1s in IIMs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>TIF1\u03b1, \u03b2 or \u03b3 expression in the skin and muscle of patients and controls was studied by immunohistochemistry. Serum myositis\u2010specific autoantibodies were detected by immunoblot.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TIF1\u03b1 was expressed in the skin of most dermatomyositis (DM) patients but not in the controls (80% vs 0%, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001). TIF1\u03b2 was expressed in all tissues of patients and controls. TIF1\u03b3 was expressed in the muscle of DM patients compared to controls (42.1% vs 0%, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.039) and associated with tubuloreticular bodies (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.003). Anti\u2010TIF1\u03b3 was related with TIF1\u03b3 expression in the muscle (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.042).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TIF1\u03b1 expression in the skin and TIF1\u03b3 in the muscle of DM was increased compared to controls. TIF1\u03b3 expression in the muscle of IIMs was related to anti\u2010TIF1\u03b3 antibody.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13424","type":"journal-article","created":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T06:29:15Z","timestamp":1541485755000},"page":"314-320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Anti\u2010TIF1\u03b3 antibody and the expression of TIF1\u03b3 in idiopathic inflammatory myopathies"],"prefix":"10.1111","volume":"22","author":[{"given":"Young","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Daejeon Veterans Hospital Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu Sang","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pathology Chungnam National University College of Medicine Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun 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