{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:45:30Z","timestamp":1792626330011,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81101388"],"award-info":[{"award-number":["81101388"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2019,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To prospectively evaluate the long\u2010term efficacy and safety of repeated sodium hyaluronate injections for the treatment of knee pain due to Kashin\u2010Beck disease (KBD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 85 patients with KBD\u2010based knee pain were treated with two cycles of a 5\u2010week course of sodium hyaluronate and received clinical assessments with a follow\u2010up period of 24\u00a0months after the first cycle. The primary efficacy measure was the visual analogue scale (VAS) pain score. The second efficacy measure included the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores; and the patients\u2019 and physicians\u2019 global assessments. Tolerability was evaluated based on adverse events (AEs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010one patients (83.5%) completed the final study. The VAS was significantly reduced from 65.06\u00a0\u00b1\u00a012.21\u00a0mm (mean\u00a0\u00b1\u00a0standard deviation [SD]) at baseline to 30.17\u00a0\u00b1\u00a011.92\u00a0mm at 6\u00a0months and was maintained for 24\u00a0months (35.79\u00a0\u00b1\u00a07.92\u00a0mm,\n                      <jats:italic>P\u00a0&lt;\u00a0<\/jats:italic>\n                      0.01 vs baseline). This finding was supported by the secondary variables (the WOMAC A, B and C scores; the total WOMAC scores; and the global assessments of the patients and their physicians at months 6, 12, 18 and 24). The overall incidence of AEs during the first and second cycles was 8 (9.4%) and 7 patients (8.2%), respectively. No serious AEs were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Repeated once yearly cycles of intra\u2010articular sodium hyaluronate injections may improve knee KBD symptoms during the inbetween cycle period as well as exert a significant carry\u2010over effect for at least 1\u00a0year after the repeated cycle. Other randomized double\u2010blind studies are needed to confirm the findings from our study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.13435","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T21:54:44Z","timestamp":1542750884000},"page":"392-398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Long\u2010term efficacy of repeated sodium hyaluronate injections in adult patients with Kashin\u2010Beck disease of the knee"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5027-1189","authenticated-orcid":false,"given":"Xin","family":"Tang","sequence":"first","affiliation":[{"name":"Orthopedic Department West China Hospital, Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zong\u2010ke","family":"Zhou","sequence":"additional","affiliation":[{"name":"Orthopedic Department West China Hospital, Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Shen","sequence":"additional","affiliation":[{"name":"Orthopedic Department West China Hospital, Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng\u2010de","family":"Kang","sequence":"additional","affiliation":[{"name":"Orthopedic Department West China Hospital, Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu\u2010xing","family":"Pei","sequence":"additional","affiliation":[{"name":"Orthopedic Department West China Hospital, Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Orthopedic Department West China Hospital, Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,20]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"343","article-title":"The history of Kashin\u2010Beck disease","volume":"89","author":"Sokoloff L","year":"1989","journal-title":"N Y State J Med"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.06.011"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.02.012"},{"key":"e_1_2_9_5_1","unstructured":"P. R. C. Ministry of Health.The prevention and control status of Kaschin\u2010Beck disease in 2011. 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