{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T06:14:07Z","timestamp":1773814447766,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T00:00:00Z","timestamp":1545955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671614"],"award-info":[{"award-number":["81671614"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2017-12M-3-001"],"award-info":[{"award-number":["2017-12M-3-001"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008235","name":"Peking Union Medical College Hospital","doi-asserted-by":"publisher","award":["2015zlgc0110"],"award-info":[{"award-number":["2015zlgc0110"]}],"id":[{"id":"10.13039\/501100008235","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008235","name":"Peking Union Medical College Hospital","doi-asserted-by":"publisher","award":["2015zlgc0709"],"award-info":[{"award-number":["2015zlgc0709"]}],"id":[{"id":"10.13039\/501100008235","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>A prospective and longitudinal study to investigate the correlations between Krebs von den Lungen\u20106 (KL\u20106) serum levels and systemic sclerosis associated with interstitial lung disease (SSc\u2010ILD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Blood samples of baseline and the time point at 2\u00a0years follow\u2010up intervals were collected for the measurement of serum KL\u20106 levels. The baseline clinical, laboratory characteristics, and incidence density of newly diagnosed ILD during the follow up were compared between SSc patients with elevated serum KL\u20106 levels (KL\u20106\u00a0&gt;\u00a0500\u00a0U\/mL) and those with normal KL\u20106 levels (KL\u20106\u00a0\u2264\u00a0500\u00a0U\/mL) at baseline. Further, we explored the association between serum KL\u20106 and deterioration of ILD measured by lung function parameters during follow\u2010up of 2\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with elevated baseline serum KL\u20106 had a significant tendency to have disappearance of the finger pad. The incidence density of new\u2010onset ILD in SSc patients with elevated baseline serum KL\u20106 and those with normal baseline serum KL\u20106 was 1.33% and 0.51%, respectively. Among the mild lung injury group, the incidence density of ILD deterioration in SSc patients with elevated baseline serum KL\u20106 and those with normal serum KL\u20106 was 1.2% and 0.74%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum KL\u20106 level correlates with the clinical manifestations of microvascular injury. Baseline elevated serum KL\u20106 may predict deterioration of lung function of SSc\u2010ILD patients with mild lung injury.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13452","type":"journal-article","created":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T11:38:31Z","timestamp":1545997111000},"page":"108-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Serum levels of Krebs von den Lungen\u20106 as a promising marker for predicting occurrence and deterioration of systemic sclerosis\u2010associated interstitial lung disease from a Chinese cohort"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3918-7146","authenticated-orcid":false,"given":"Xiao\u2010yu","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Graduate School of Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sha\u2010sha","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Graduate School of Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Graduate School of Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng\u2010tao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking 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