{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:06:18Z","timestamp":1780319178983,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T00:00:00Z","timestamp":1544486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T00:00:00Z","timestamp":1544486400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2019,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify factors associated with deterioration of pulmonary function with disproportional decline in diffusing capacity for carbon monoxide (DLCO) relative to forced vital capacity (FVC) in patients with dermatomyositis (DM) and polymyositis (PM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included patients with DM and PM, in whom serial pulmonary function tests were available. Changes in FVC and DLCO over time were estimated using a linear mixed\u2010effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 103 patients were included. During follow\u2010up, 31 (30.1%) and 37 (35.9%) had a disproportionally better (\u0394DLCO\/\u0394FVC&gt;mean slope + 95% CI) or a disproportionally worse (\u0394DLCO\/\u0394FVC &lt;mean slope \u2013 95% CI) DLCO change relative to FVC change. After adjusting for age, gender and diagnosis, Raynaud's phenomenon (RP) and anti\u2010nuclear antibodies (ANA) increased the risk of disproportional DLCO decline (odds ratio [OR]: 6.32, 95% CI: 1.34\u201029.81,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a00.022; OR: 3.92, 95% CI: 1.21\u201012.67,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a00.020, respectively). Patients with ANA and RP tended to deteriorate, whereas those without ANA and RP improved (FVC: \u22124.5\u00a0\u00b1\u00a014.4 vs 11.1%\u00a0\u00b1\u00a027.5%\/y,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a00.38; DLCO: \u221217.0\u00a0\u00b1\u00a024.9 vs 9.8%\u00a0\u00b1\u00a025.4%\/year,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a00.015). More patients with ANA and RP tended to reach progressive DLCO decline (DLCO &lt;40%) than ANA\/RP\u2010negative patients (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a00.05). Trends toward higher rates of pulmonary hypertension and higher systolic pulmonary arterial pressure were observed in those with both ANA and RP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study identifies RP and ANA as risk factors for the deterioration of pulmonary function with disproportional DLCO decline relative to FVC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.13456","type":"journal-article","created":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T00:23:48Z","timestamp":1544574228000},"page":"507-515","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Raynaud\u2019s phenomenon and anti\u2010nuclear antibody are associated with pulmonary function decline in patients with dermatomyositis and polymyositis"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6813-4182","authenticated-orcid":false,"given":"Eun Hye","family":"Park","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Seoul National University Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Chang","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Statistics, Data Science for Knowledge Creation Research Center Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngjo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Statistics, Data Science for Knowledge Creation Research Center Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Seoul National University Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0703-1208","authenticated-orcid":false,"given":"Eun Bong","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Seoul National University Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5384-3437","authenticated-orcid":false,"given":"Yeong Wook","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Seoul National University Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Kyun","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Seoul National University Hospital  Seoul 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