{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T07:27:59Z","timestamp":1770708479439,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,10]],"date-time":"2019-02-10T00:00:00Z","timestamp":1549756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31470039"],"award-info":[{"award-number":["31470039"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["Z141107002514064"],"award-info":[{"award-number":["Z141107002514064"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the impact of corticosteroids on the outcome of antiviral therapy in rheumatic patients with cytomegalovirus (CMV)\u2010emia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Sixty\u2010two patients with rheumatic disease complicated by CMV infection from 2011 to 2014 were retrospectively analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010five of 62 patients were diagnosed with CMV\u2010DNAemia. Most patients (43\/55, 78.2%) achieved viral clearance within 5\u00a0weeks. It was shown that, while undergoing active antiviral therapy, there was no significant difference in the CMV\u2010DNAemia clearance rate between the pulse methylprednisolone (MPSL) therapy group and non\u2010pulse group (8\/9, 88.9% vs 30\/36, 83.3%; OR\u00a0=\u00a01.600, 95% CI 0.168\u201015.273, <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05) at the end of the 5\u2010week follow\u2010up. However, pulse MPSL might slightly prolong duration of CMV\u2010DNAemia than non\u2010pulse MPSL patients (20.78\u00a0\u00b1\u00a019.18\u00a0days vs 14.33\u00a0\u00b1\u00a09.01\u00a0days, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.1430), especially in the high baseline titer group (33.7\u00a0\u00b1\u00a029.1\u00a0days in pulse MPSL group vs 18.3\u00a0\u00b1\u00a013.1\u00a0days in non\u2010pulse group, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.457). But in the low baseline titer group, CMVemia duration in the pulse MPSL group (14.3\u00a0\u00b1\u00a010.0\u00a0days) was about the same as that in the non\u2010pulse MPSL group (13.4\u00a0\u00b1\u00a07.8\u00a0days).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>With effective antiviral therapy, pulse MPSL is acceptable in rheumatic disease patients with CMV\u2010DNAemia, without significant impact on final clearance of virus. However, duration of CMV\u2010DNAemia may be prolonged, especially in patients with high CMV\u2010DNA titer at baseline.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13467","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T05:44:44Z","timestamp":1549863884000},"page":"583-591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pulse corticosteroids in treatment of rheumatic disease concomitant with cytomegalovirus infection"],"prefix":"10.1111","volume":"22","author":[{"given":"Yan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, Peking University People's Hospital Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135) Peking\u2010Tsinghua Center for Life Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limin","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Peking University People's Hospital Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135) Peking\u2010Tsinghua Center for Life Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4107-894X","authenticated-orcid":false,"given":"Xu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Peking University People's Hospital Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135) Peking\u2010Tsinghua Center for Life Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Peking University People\u2019s Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanlei","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Peking University People's Hospital Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135) Peking\u2010Tsinghua Center for Life Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanguo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Peking University People's Hospital Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135) Peking\u2010Tsinghua Center for Life Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00692.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.655"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0639-6"},{"issue":"34","key":"e_1_2_8_5_1","first-page":"2426","article-title":"Analysis of cytomegaloviral antigenemia test and re\u2010test after antiviral chemotherapy in patients with autoimmune and non\u2010autoimmune diseases","volume":"92","author":"Cui JT","year":"2012","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/522429"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2003.00647.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc10069"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-2131-4"},{"issue":"7","key":"e_1_2_8_10_1","first-page":"1349","article-title":"Incidence of cytomegalovirus reactivation in patients with inflammatory connective tissue diseases who are under immunosuppressive therapy","volume":"31","author":"Mori T","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_8_11_1","first-page":"40","volume-title":"WHO Expert Committee on Biological Standardization. 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