{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T10:55:08Z","timestamp":1753354508965,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Overhead research fund of Ramanth Misra"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>After exclusion of reactive, psoriatic and enteritis\u2010associated arthritis, a group of \u201cundifferentiated\u201d peripheral spondyloarthritis (pSpA) remains. This group shares genetics, T\u2010cell repertoire, and cytokines with reactive arthritis (ReA). ReA is preceded by gut or urogenital infection. Otherwise the two may be similar. We know little of the metabolic pathways driving undifferentiated pSpA or ReA. Nuclear magnetic resonance (NMR)\u2010based metabolomics presents a hypothesis\u2010free approach to study and compare metabolic pathways driving undifferentiated pSpA and ReA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum and synovial fluid metabolomes of 19 ReA and 13 undifferentiated pSpA, and serum metabolome of 18 controls were profiled using <jats:sup>1<\/jats:sup>H\u2010based NMR. Partial least square\u2010discriminant analysis (PLS\u2010DA) identified metabolites different in patients as compared to controls. Multivariate analysis confirmed these. Altered metabolic pathways were identified using metabolites set enrichment analysis (MSEA). The serum and synovial fluid metabolomes of ReA and undifferentiated pSpA were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten serum metabolites of ReA\/undifferentiated pSpA were different from those of controls. Six metabolites were different between serum and synovial fluid of these patients. MSEA identified five pathways different between patients and controls, and five pathways different between serum and synovial fluid of patients. PLS\u2010DA showed no difference between the metabolomes of serum or of synovial fluid between ReA and undifferentiated pSpA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Identified metabolic pathways may be explored further to understand the pathogenesis and to target therapeutics. The similar immuno\u2010metabolic pathways suggest similar pathogenesis of ReA and undifferentiated pSpA. Thus, they should be studied as a single disease entity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13490","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T10:48:48Z","timestamp":1551264528000},"page":"725-733","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Nuclear magnetic resonance\u2010based metabolomics reveals similar metabolomics profiles in undifferentiated peripheral spondyloarthritis and reactive arthritis"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4631-311X","authenticated-orcid":false,"given":"Sakir","family":"Ahmed","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Durgesh","family":"Dubey","sequence":"additional","affiliation":[{"name":"Centre of Biomedical Research Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5143-0025","authenticated-orcid":false,"given":"Abhra","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smriti","family":"Chaurasia","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anupam","family":"Guleria","sequence":"additional","affiliation":[{"name":"Centre of Biomedical Research Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajeev","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8079-6739","authenticated-orcid":false,"given":"Dinesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Centre of Biomedical Research Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7921-4199","authenticated-orcid":false,"given":"Ramnath","family":"Misra","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.108233"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-017-3720-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12799"},{"key":"e_1_2_7_5_1","first-page":"16","article-title":"Dysregulated cytokine and chemokine profiles in synovial fluid of patient with ReA\/uSpA. Poster Presentations","volume":"12","author":"Kumar S","year":"2017","journal-title":"Indian J Rheumatol"},{"key":"e_1_2_7_6_1","first-page":"725","article-title":"Metabolomics toward personalized medicine","author":"Jacob M","year":"2017","journal-title":"Mass Spectrom Rev"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206618"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40223"},{"issue":"9","key":"e_1_2_7_9_1","first-page":"2185","article-title":"On the difficulties of establishing a consensus on the definition of and diagnostic investigations for reactive arthritis. Results and discussion of a questionnaire prepared for the 4th International Workshop on Reactive Arthritis, Berlin, Germany, July 3\u20106, 1999","volume":"27","author":"Braun J","year":"2000","journal-title":"J Rheumatol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.5b00422"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-507"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2014.03.012"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05439-1"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.141505"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2016.02.004"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1139-2"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/b807369d"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M111.013904"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.08.064"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0162-3109(89)90064-7"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0162-3109(91)90053-2"},{"issue":"5","key":"e_1_2_7_22_1","first-page":"RA79\u201084","article-title":"Pyruvate is an endogenous anti\u2010inflammatory and anti\u2010oxidant molecule","volume":"12","author":"Das UN","year":"2006","journal-title":"Med Sci Monit"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4375"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3804"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201300084"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00789-13"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2007.00449.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00452.2009"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2011.04519.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-07-0306"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.4.337"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.04.024"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.13490","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.13490","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.13490","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.13490","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T18:53:56Z","timestamp":1694285636000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.13490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,27]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1111\/1756-185X.13490"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.13490","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"type":"print","value":"1756-1841"},{"type":"electronic","value":"1756-185X"}],"subject":[],"published":{"date-parts":[[2019,2,27]]},"assertion":[{"value":"2018-05-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}