{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T22:21:17Z","timestamp":1784758877624,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T00:00:00Z","timestamp":1549411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Small intestinal bacterial overgrowth (SIBO) results in nutrient malabsorption and malnutrition, thereby increasing the morbidity and mortality in systemic sclerosis (SSc) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the prevalence and associated factors of SIBO in SSc patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A cross\u2010sectional study was conducted between July 2015 and January 2016 in SSc patients over 18, using the glucose H<jats:sub>2<\/jats:sub>\/CH<jats:sub>4<\/jats:sub> breath test to evaluate SIBO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010nine SSc patients (30 male and 59 female) underwent the glucose H<jats:sub>2<\/jats:sub>\/CH<jats:sub>4<\/jats:sub> breath test. The mean age was 54.4. Twelve participants were positive for the glucose H<jats:sub>2<\/jats:sub>\/CH<jats:sub>4<\/jats:sub> breath test, yielding a SIBO prevalence of 13.5% (95% CI 7.2\u201022.4) among SSc patients. A multivariate analysis revealed that duration of disease &gt;5\u00a0years was significantly associated with SIBO (adjusted odds ratio 9.38; 95% CI 1.09\u201080.47).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of SIBO, using the glucose H<jats:sub>2<\/jats:sub>\/CH<jats:sub>4<\/jats:sub> breath test, is not common among Thai SSc patients. However, a positive result was associated with longer duration of disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13495","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T07:33:24Z","timestamp":1549524804000},"page":"695-699","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Prevalence and associated factors of small intestinal bacterial overgrowth among systemic sclerosis patients"],"prefix":"10.1111","volume":"22","author":[{"given":"Kookwan","family":"Sawadpanich","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Division of Gastroenterology, Department of Medicine Khon Kaen University Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pisit","family":"Soison","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Division of Gastroenterology, Department of Medicine Khon Kaen University Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kitti","family":"Chunlertrith","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Division of Gastroenterology, Department of Medicine Khon Kaen University Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pisaln","family":"Mairiang","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Division of Gastroenterology, Department of Medicine Khon Kaen University Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wattana","family":"Sukeepaisarnjaroen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Division of Gastroenterology, Department of Medicine Khon Kaen University Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apichat","family":"Sangchan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Division of Gastroenterology, Department of Medicine Khon Kaen University Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanita","family":"Suttichaimongkol","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Division of Gastroenterology, Department of Medicine Khon Kaen University Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1964-4389","authenticated-orcid":false,"given":"Chingching","family":"Foocharoen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Division of Allergy\u2010Immunology\u2010Rheumatology, Department of Medicine Khon Kaen University Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e318042d625"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02207649"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573397113666170425145405"},{"issue":"6","key":"e_1_2_9_5_1","first-page":"S\u201082","article-title":"Prevalence and predictors of small intestinal bacterial overgrowth in systemic sclerosis patients with gastrointestinal symptoms","volume":"32","author":"Tauber M","year":"2014","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(69)90044-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117395"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-8-7"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-0018-8"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196606162742402"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/34.3.265"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/34.10.976"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2006.02547.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199111213252102"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i24.2978"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000336174"},{"issue":"1","key":"e_1_2_9_17_1","first-page":"695","article-title":"Methodology and indications of H2\u2010breath testing in gastrointestinal diseases: the Rome Consensus Conference","volume":"29","author":"Gasbarrini A","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230510"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)91339-8"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.45.6016"},{"issue":"1","key":"e_1_2_9_21_1","first-page":"6","article-title":"Utility of hydrogen breath tests in diagnosis of small intestinal bacterial overgrowth in malabsorption syndrome and its relationship with oro\u2010cecal transit time","volume":"25","author":"Ghoshal UC","year":"2006","journal-title":"Indian J Gastroenterol"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-0065-1"},{"issue":"2","key":"e_1_2_9_23_1","first-page":"202","article-title":"Scleroderma (systemic sclerosis): classification, subsets and pathogenesis","volume":"15","author":"LeRoy EC","year":"1988","journal-title":"J Rheumatol"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep226"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01758.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes429"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.13495","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.13495","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.13495","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.13495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T18:54:03Z","timestamp":1694285643000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.13495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,6]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1111\/1756-185X.13495"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.13495","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,6]]},"assertion":[{"value":"2017-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}