{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:30:09Z","timestamp":1747182609046,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T00:00:00Z","timestamp":1555286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We evaluated the effects of anti\u2010tumor necrosis factor (TNF) agents on health economics in ankylosing spondylitis (AS) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>QUality of Life as Outcomes and its VAriation with DIsease States (QUO\u2010VADIS) was a prospective observational study following bio\u2010na\u00efve AS patients (modified New York criteria) newly treated with golimumab (GLM) or infliximab (IFX; originator) in a clinical practice setting over 6\u00a0months. We evaluated use of concomitant medications, hospitalizations (in\u2010patient care or acute care) and visits in day care and out\u2010patient settings for the assessment of healthcare resource utilization (HCRU). Work productivity and activity impairment (WPAI) was assessed by the number of work days missed and quantifying absenteeism, presenteeism, work impairment, and activity using the WPAI instrument adapted to spondyloarthritis (WPAI\u2010SpA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine hundred and sixty\u2010three patients received \u22651 dose of medication (78%, n\u00a0=\u00a0751 GLM; 22%, n\u00a0=\u00a0221 IFX). Mean age was 42.7\u00a0years; 61.4% were male. At baseline, the percentage of patients who reported hospitalizations (in\u2010patient care) was 13.6%, which decreased to 3.1% at 6\u00a0months, while out\u2010patient care at baseline was reported by 39.4% of patients, which decreased to 19.0% at 6\u00a0months. The percentage of patients receiving acute emergency at baseline reduced from 1.6% to 0.3% at 6\u00a0months. The mean (SD) number of days of work missed due to AS, was reduced from 6.3 (31.1) days at baseline to 2.7 (12.3) days at 6\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with AS newly treated with GLM or IFX for 6\u00a0months, HCRU was reduced and work productivity and activity increased.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13526","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T01:35:04Z","timestamp":1555378504000},"page":"995-1001","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Treatment with golimumab or infliximab reduces health resource utilization and increases work productivity in patients with ankylosing spondylitis in the QUO\u2010VADIS study, a large, prospective real\u2010life cohort"],"prefix":"10.1111","volume":"22","author":[{"given":"Pascal","family":"Claudepierre","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Henri Mondor Hospital, APHP and Universit\u00e9 Paris Est Cr\u00e9teil Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filip","family":"Van den Bosch","sequence":"additional","affiliation":[{"name":"Ghent University Hospital Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piercarlo","family":"Sarzi\u2010Puttini","sequence":"additional","affiliation":[{"name":"UOC Reumatologia, Ospedale L. Sacco Polo Universitario Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Vastesaeger","sequence":"additional","affiliation":[{"name":"MSD Belgium Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marinella","family":"Govoni","sequence":"additional","affiliation":[{"name":"MSD Italy Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7190-6323","authenticated-orcid":false,"given":"Sumesh","family":"Kachroo","sequence":"additional","affiliation":[{"name":"Merck &amp; Co., Inc Kenilworth New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60635-7"},{"issue":"4","key":"e_1_2_7_3_1","first-page":"S136","article-title":"A systematic literature review of the economic impact of ankylosing 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