{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T06:19:01Z","timestamp":1768457941453,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To clarify the development of juvenile idiopathic arthritis (JIA) to adult\u2010onset autoimmune diseases in a population\u2010based study in Taiwan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed data of 107\u00a0433 children born between 1990 and 1997 from the National Taiwan Health Insurance Database. There were 262 JIA patients and 107\u00a0171 individuals without JIA who were selected and followed up until December 2013 to investigate their outcomes of adult\u2010onset autoimmune diseases after reaching 16\u00a0years of age. The adjusted hazard ratios (aHRs) including 95% confidence intervals (95% CI) of adult\u2010onset autoimmune diseases were calculated using the Cox proportional regression model among different age groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence rate for patients with a history of JIA was 83.56 per 10<jats:sup>5<\/jats:sup> person\u2010months for rheumatoid arthritis (RA), 16.61 for systemic lupus erythematosus (SLE), 58.39 for ankylosing spondylitis (AS), and 33.26 for psoriatic diseases. The aHRs were 29.60 for any autoimmune disease, 129.52 for RA, 10.01 for SLE, 49.62 for AS, and 8.20 for psoriatic diseases. Compared with non\u2010JIA individuals, the aHRs of adult\u2010onset autoimmune diseases were 34.87 (95% CI: 4.85\u2010250.62) at the onset age of 3\u20105\u00a0years, 12.01 (95% CI: 2.99\u201048.26) at the age of 6\u201010\u00a0years, and 45.80 (95% CI: 29.69\u201070.64) at the age of 11\u201015\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Children with JIA were at an increased risk of developing RA, AS, psoriatic disease, and SLE in adulthood.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13527","type":"journal-article","created":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T07:45:38Z","timestamp":1551339938000},"page":"1283-1288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Adult outcome of juvenile idiopathic arthritis: A nationwide population\u2010based retrospective cohort study in Taiwan"],"prefix":"10.1111","volume":"22","author":[{"given":"Su\u2010Boon","family":"Yong","sequence":"first","affiliation":[{"name":"Institute of Medicine Chung Shan Medical University Taichung Taiwan"},{"name":"Division of Pediatric Allergy, Immunology and Rheumatology, Department of Pediatrics Show Chwan Memorial Hospital Changhua Taiwan"},{"name":"Department of Nursing Meiho University Pingtung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing\u2010Yang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medical Research Chung Shan Medical University Hospital Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeng\u2010Yuan","family":"Chiou","sequence":"additional","affiliation":[{"name":"School of Health Policy and Management Chung Shan Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1235-0679","authenticated-orcid":false,"given":"James Cheng\u2010Chung","family":"Wei","sequence":"additional","affiliation":[{"name":"Institute of Medicine Chung Shan Medical University Taichung Taiwan"},{"name":"Division of Allergy, Immunology and Rheumatology Chung Shan Medical University Hospital Taichung Taiwan"},{"name":"Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60244-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2014.01.009"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.02.001"},{"key":"e_1_2_6_5_1","first-page":"1520","article-title":"Worldwide prevalence of juvenile arthritis why does it vary so much?","volume":"29","author":"Manners PJ","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009741003742722"},{"key":"e_1_2_6_7_1","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty RE","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2018.01.002"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00393-007-0246-5"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh531"},{"key":"e_1_2_6_11_1","first-page":"310","article-title":"Autoimmune endocrine disorders and coeliac disease in children and adolescents with juvenile idiopathic arthritis and rheumatic fever","volume":"31","author":"Robazzi TC","year":"2013","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-017-0373-9"},{"key":"e_1_2_6_13_1","unstructured":"National Health Research Institutes.National Health Insurance Research Database. 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