{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:39:16Z","timestamp":1761863956825,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T00:00:00Z","timestamp":1551657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We investigated the association between systemic sclerosis (SSc) and perioperative cardiovascular risk for inpatient non\u2010cardiac surgical procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used data from the National Inpatient Sample (NIS) for the year 2014 to identify patients undergoing inpatient non\u2010cardiac surgery. SSc and major adverse cardiovascular events (MACE) were defined by International Classification of Diseases 9th Revision diagnosis codes. Univariate and multivariate analyses were performed. We adjusted for demographic information, socioeconomic status, cardiac comorbidities, cardiovascular risk factors and procedural category. Two models were used with different categorization strategies for surgical procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 8\u00a0156\u00a0379 hospitalizations for non\u2010cardiac surgeries were included, 4385 of which had a diagnosis of SSc. Patients with SSc were older, more likely to be female and Caucasian and with higher cardiac and systemic comorbidity burden. In univariate analysis, SSc was associated with higher risk of perioperative MACE (odds ratio [OR]\u00a0=\u00a02.9; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and all\u2010cause death (<jats:italic>P<\/jats:italic>\u00a0=\u00a03.07; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Multivariate analysis yielded conflicting results regarding the association between SSc and perioperative MACE (Model 1: OR\u00a0=\u00a01.42; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.146; Model 2: OR\u00a0=\u00a01.59; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.048). Subsequent analysis showed that only perioperative myocardial infarction (Model 1 OR\u00a0=\u00a01.85; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.048; Model 2 OR\u00a0=\u00a01.94; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.031) was independently associated with SSc.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We did not find consistent association between SSc and perioperative MACE in non\u2010cardiac surgical procedures. SSc may be associated with perioperative myocardial infarction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13537","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T03:11:21Z","timestamp":1551755481000},"page":"1023-1028","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Systemic sclerosis and the risk of perioperative major adverse cardiovascular events for inpatient non\u2010cardiac surgery"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7710-2425","authenticated-orcid":false,"given":"Yiming","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Medicine, Mount Sinai St Luke\u2019s and Mount Sinai West Hospitals Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changchuan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Mount Sinai St Luke\u2019s and Mount Sinai West Hospitals Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chayakrit","family":"Krittanawong","sequence":"additional","affiliation":[{"name":"Department of Medicine, Mount Sinai St Luke\u2019s and Mount Sinai West Hospitals Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Belen","family":"Arevalo Molina","sequence":"additional","affiliation":[{"name":"Department of Medicine, Mount Sinai St Luke\u2019s and Mount Sinai West Hospitals Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shane","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Medicine, Mount Sinai St Luke\u2019s and Mount Sinai West Hospitals Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology China PLA General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianglin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology China PLA General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Salgado","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jacobi Medical Center Albert Einstein College of Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiehui","family":"Xu","sequence":"additional","affiliation":[{"name":"Mailman School of Public Health Columbia University Medical Center New York New 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