{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:42:26Z","timestamp":1787013746575,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T00:00:00Z","timestamp":1551830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701606"],"award-info":[{"award-number":["81701606"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["19YYJC2976"],"award-info":[{"award-number":["19YYJC2976"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["16PJ284"],"award-info":[{"award-number":["16PJ284"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009564","name":"Health and Family Planning Commission of Sichuan Province","doi-asserted-by":"publisher","award":["16PJ284"],"award-info":[{"award-number":["16PJ284"]}],"id":[{"id":"10.13039\/501100009564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aims to discuss plasma and messenger RNA (mRNA) levels of interleukin (IL)\u201037 in rheumatoid arthritis (RA) patients and evaluate the potential of plasma IL\u201037 as a biomarker for RA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Plasma IL\u201037 levels and IL\u201037 mRNA relative concentrations were measured by enzyme\u2010linked immunosorbent assay (ELISA) and quantitative reverse transcriptase\u2010polymerase chain reaction (RT\u2010PCR). We discussed the association of IL\u201037 levels and clinical, laboratory parameters in RA patients in a training cohort. Plasma IL\u201037 levels were tested for discriminatory capacity by receiver operating characteristic (ROC) curve analysis. We then validated plasma IL\u201037 expression in a cohort of 598 patients (230 RA, 107 systemic lupus erythematosus [SLE], 100 osteoarthritis [OA], 62 gout, 51 primary Sj\u00f6gren's syndrome [pSS], 48 ankylosing spondylitis [AS]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both plasma levels of IL\u201037 and mRNA levels of IL\u201037 were elevated in RA patients compared to those in healthy controls in the training cohort, and there was a good diagnostic ability to predict RA (area under the curve [AUC]\u00a0=\u00a00.97). Plasma IL\u201037 levels were significantly related to Disease Activity Score of 28 joints \u2010 erythrocyte sedimentation rate (DAS28\u2010ESR) (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>s<\/jats:sub>\n                      \u00a0=\u00a00.459,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &lt;\u00a00.001). The levels of IL\u201037 mRNA were related to plasma IL\u201037 levels (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>s<\/jats:sub>\n                      \u00a0=\u00a00.642,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &lt;\u00a00.001), DAS28\u2010ESR (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.641,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and C\u2010reactive protein (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>s<\/jats:sub>\n                      \u00a0=\u00a00.603,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). In the validation cohort, when plasma IL\u201037 in RA patients compared with that in SLE, OA, gout, pSS and AS patients, the AUC was 0.86, 0.87, 0.91, 0.87, 0.92, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IL\u201037 expression was increased in RA patients, and correlated with disease activity. IL\u201037 may be a biomarker for the diagnosis of RA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.13539","type":"journal-article","created":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T22:06:50Z","timestamp":1551910010000},"page":"1123-1129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Elevated expression of interleukin\u201037 in patients with rheumatoid arthritis"],"prefix":"10.1111","volume":"22","author":[{"given":"Zhi\u2010Chao","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Evidence\u2010Based Medicine, School of Public Health Southwest Medical University Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Evidence\u2010Based Medicine, School of Public Health Southwest Medical University Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3860-8383","authenticated-orcid":false,"given":"An\u2010Fang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Affiliated Hospital of Southwest Medical University Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin\u2010Chong","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Affiliated Minda Hospital of Hubei Institute for Nationalities Enshi Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang\u2010Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Evidence\u2010Based Medicine, School of Public Health Southwest Medical University Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8276-1249","authenticated-orcid":false,"given":"Wang\u2010Dong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Evidence\u2010Based Medicine, School of Public Health Southwest Medical University Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30173-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12873"},{"key":"e_1_2_8_4_1","first-page":"1123","article-title":"Adverse events, clinical considerations and management recommendations in rheumatoid arthritis patients treated with JAK inhibitors","volume":"21","author":"Atzeni F","year":"2018","journal-title":"Expert Rev Clin Immunol"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39953"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37816"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S91374"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27334"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201601"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001107"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.14.10308"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1944"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3058640"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.8.5477"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.08.006"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095346"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700009934"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200320"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.6.554"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1449-z"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095346"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401810"},{"key":"e_1_2_8_26_1","first-page":"1123","article-title":"(2015) Plasma Interleukin\u201037 Is Elevated in Patients with Rheumatoid Arthritis: Its Correlation with Disease Activity and Th1\/Th2\/Th17\u2010Related Cytokines","volume":"2","author":"Xia T","year":"2015","journal-title":"Dis Markers"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2018.07.027"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.909254"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463201202500105"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2013.06.190"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004462"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-11-200706050-00008"},{"issue":"1","key":"e_1_2_8_33_1","first-page":"85","article-title":"Diagnostic value of antibodies against mutated citrullinated vimentin for rheumatoid arthritis","volume":"29","author":"Besada E","year":"2011","journal-title":"Clin Exp Rheumatol"},{"issue":"11","key":"e_1_2_8_34_1","doi-asserted-by":"crossref","first-page":"5687","DOI":"10.4049\/jimmunol.159.11.5687","article-title":"Suppression of collagen\u2010induced arthritis by continuous administration of il\u20104","volume":"159","author":"Horsfall AC","year":"1997","journal-title":"J Immunol"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301165"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.5.2755"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152812800392805"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.13539","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.13539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T07:49:02Z","timestamp":1694332142000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.13539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,6]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/1756-185X.13539"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.13539","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,6]]},"assertion":[{"value":"2018-10-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}