{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:26:16Z","timestamp":1762917976889,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T00:00:00Z","timestamp":1552867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We conducted this retrospective study to identify objective and comprehensive diagnostic criteria for early\u2010stage rheumatoid arthritis (RA) that are based on ultrasound (US) and serologic findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>From August 2014 to May 2016, we recruited 216 consecutive patients at Hospital 1 and 223 consecutive patients at Hospital 2 who were suspected to have RA and underwent US of bilateral hands. In the US of bilateral hands from 22 sites, the findings obtained by grayscale and power Doppler (PD) assessments were each graded on a semi\u2010quantitative scale from 0 to 3. We also examined the assessment of the novel outcome measures in rheumatology (OMERACT)\u2010European League Against Rheumatism (EULAR) combined power Doppler ultrasound score (ie the cPD score) and the Global OMERACT\u2010EULAR Synovitis Score. We used the US findings and the combination of US and serologic findings to evaluate the diagnostic performance of these modalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy patients (32.4%) at Hospital 1 and 59 patients (26.5%) at Hospital 2 were diagnosed as having RA. The best\u2010balanced diagnostic performance at each hospital was achieved using a combination, such as (1) the presence of PD grade \u22652 articular synovitis or (2) the presence of PD grade \u22651 articular synovitis and serologic positivity, as well as by using (1) the presence of cPD grade\u00a0=\u00a03 or (2) a cPD grade \u22652 and serologic positivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of a PD assessment or the cPD score with the measurement of autoantibodies of rheumatoid factor and\/or anti\u2010cyclic citrullinated peptide antibodies can accurately identify patients with early\u2010stage RA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13543","type":"journal-article","created":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T19:43:49Z","timestamp":1552938229000},"page":"842-851","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Combination of ultrasound power Doppler\u2010verified synovitis and seropositivity accurately identifies patients with early\u2010stage rheumatoid arthritis"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2606-995X","authenticated-orcid":false,"given":"Shin\u2010ya","family":"Kawashiri","sequence":"first","affiliation":[{"name":"Department of Community Medicine Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan"},{"name":"Department of Immunology and Rheumatology Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Fujikawa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Isahaya General Hospital Isahaya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Nishino","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology Nagasaki University 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