{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:23:08Z","timestamp":1790234588280,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T00:00:00Z","timestamp":1555372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373181"],"award-info":[{"award-number":["81373181"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571595"],"award-info":[{"award-number":["81571595"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>\u2009Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Axial spondyloarthritis (axSpA) is a chronic inflammatory arthritis involving the axial skeleton. Recent evidence suggests that microRNAs (miRNAs) play a critical role in ankylosing spondylitis (AS). In this study, we aimed to investigate whether miR\u201017\u20105p, miR\u201027a, miR\u201029a and miR\u2010126\u20103p can be verified as potential biomarkers of axSpA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Peripheral blood mononuclear cell (PBMC) miRNA expression was evaluated by quantitative real\u2010time polymerase chain reaction among 43 patients with AS, 26 patients with non\u2010radiographic axSpA (nr\u2010axSpA) and 39 healthy controls. Detailed clinical histories were recorded and the correlation of miRNAs and clinical features were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When compared to controls, both patients with AS and nr\u2010axSpA had significantly higher expression levels of miR\u201017\u20105p, miR\u201027a, miR\u201029a and miR\u2010126\u20103p. MiR\u201027a was negatively correlated with Ankylosing Spondylitis Disease Activity Score as well as C\u2010reactive protein in patients with nr\u2010axSpA (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.51, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01 and <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.42, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.034 respectively). No other clinical features were found to correlate with the four miRNAs in patients with AS. Mir\u201029a showed highest area under the curve with 0.952 and these four miRNAs may be potential biomarkers in patients with axSpA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We reported elevated miR\u201017\u20105p, miR\u201027a, miR\u201029a and miR\u2010126\u20103p expression in PBMCs of patients with axSpA, and the expression of these four miRNAs might be used as useful diagnostic markers in axSpA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13563","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T12:14:49Z","timestamp":1555416889000},"page":"1188-1195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Aberrant expression of microRNAs in peripheral blood mononuclear cells as candidate biomarkers in patients with axial spondyloarthritis"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3614-3244","authenticated-orcid":false,"given":"Xiaomin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Rheumatology the Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Rheumatology the Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liudan","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology the Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology the Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peizhuo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Suzhou GenePharma Co., Ltd. Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuxia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology the Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiujing","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Rheumatology the Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangyan","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology the Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieruo","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology the Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou 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