{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T15:55:22Z","timestamp":1779206122847,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T00:00:00Z","timestamp":1561593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571587"],"award-info":[{"award-number":["81571587"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771757"],"award-info":[{"award-number":["81771757"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The purpose of this study is to evaluate the therapeutic efficacy and safety of iguratimod plus corticosteroid as bridge therapy in the treatment of mild immunoglobulin G4\u2010related disease (IgG4\u2010<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Newly diagnosed IgG4\u2010<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content> patients, without internal organ involvement were enrolled. Patients were given one dose of diprospan, intramuscular injection, and iguratimod, 25\u00a0mg, twice daily, for 24\u00a0weeks and were followed up at 0, 12 and 24\u00a0weeks. Follow\u2010up indexes included IgG4\u2010<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content> responder index (IgG4\u2010<jats:styled-content style=\"fixed-case\">RD RI<\/jats:styled-content>), serology and imaging, plasma cytokines and adverse drug effect. Flow cytometry was performed for T, B cell subsets and plasma was collected for liquid chromatography mass spectrometry (<jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>)\u2010based metabolomic profiling and data processing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty patients were enrolled. At week 24, 9 (30.0%) patients achieved complete response, 17 (56.7%) patients with partial response, and 4 (13.3%) patients had no response to treatment. IgG4\u2010<jats:styled-content style=\"fixed-case\">RD RI<\/jats:styled-content>, serum IgG and IgG4 levels decreased significantly at weeks 12 and 24 after treatment, as well as <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3+ <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8+ T cells, plasmablast\/plasma cells and memory B cells. The <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> based plasma metabolomic profiles revealed significant changes between untreated patients and healthy donors, which became much similar to normal states after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Iguratimod plus corticosteroid as bridge therapy is effective for the treatment of mild IgG4\u2010<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>, it can improve the clinical symptoms, reduce serum IgG and IgG4 levels, especially plasmablasts\/plasma cells and memory B cells. In addition, the metabolite profiling became similar to normal controls after treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13633","type":"journal-article","created":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T11:36:10Z","timestamp":1561635370000},"page":"1479-1488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Efficacy and safety of iguratimod plus corticosteroid as bridge therapy in treating mild IgG4\u2010related diseases: A prospective clinical trial"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4120-8943","authenticated-orcid":false,"given":"Panpan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Rheumatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing China"},{"name":"Key Laboratory of Rheumatology and Clinical Immunology Ministry of Education 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