{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:30:22Z","timestamp":1747182622191,"version":"3.40.5"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T00:00:00Z","timestamp":1565913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Human \u03b1\u2010fucosidase (EC 3.2.1.51) is a hydrolase the importance of which has been increasing in the latest years. However, data about its plasma level in children with autoimmune disorders, particularly Sj\u00f6gren's syndrome (SS), are lacking. In this study, the plasma activity of L\u2010\u03b1\u2010fucosidase\u20101 (\u03b1\u2010L\u2010FUCA\u20101) was assayed in hospitalized children and adults and its association with SS and other rheumatic disorders further evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total 73 Hungarian hospitalized patients, 32 children (2.5\u201010\u00a0years) and 41 adults (32\u201068\u00a0years), were enrolled in the study and underwent plasma assay of \u03b1\u2010L\u2010FUCA1 activity. Linear regression, Durbin\u2010Watson (DW), and Pearson tests were evaluated to investigate the relationship between \u03b1\u2010L\u2010FUCA\u20101 plasma levels and autoimmune manifestations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>\u03b1\u2010L\u2010FUCA\u20101 correlated with SS both in children (2\u2010sided <jats:italic>t<\/jats:italic> test, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0023) and in adults (2\u2010sided <jats:italic>t<\/jats:italic> test, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.00035). Linear regressions showed that in other rheumatic disorders, \u03b1\u2010L\u2010FUCA1 did not show any differential distribution related to the particular pathology (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.2042, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.1531, DW test\u00a0=\u00a02.2139 positive), while this trend was radically opposite for patients with SS (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.1462, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0032, DW test\u00a0=\u00a01.3664, negative).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Alterations in plasma level of \u03b1\u2010L\u2010FUCA\u20101 were significantly associated with SS. This preliminary result should encourage further research on \u03b1\u2010L\u2010FUCA\u20101 as a possible differential serological marker of SS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13639","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T12:58:44Z","timestamp":1565960324000},"page":"1762-1767","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Plasma \u03b1\u2010L\u2010fucosidase\u20101 in patients with Sj\u00f6gren's syndrome and other rheumatic disorders"],"prefix":"10.1111","volume":"22","author":[{"given":"Ildik\u00f3","family":"Endreffy","sequence":"first","affiliation":[{"name":"Department of Pediatrics J\u00f3sa Andr\u00e1s County Hospital Ny\u00edregyh\u00e1za 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