{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:30:29Z","timestamp":1747182629821,"version":"3.40.5"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>It is commonly assumed that a genetically determined polymorphism of xenobiotic biotransformation plays a particular role in the development of such disease entities in which chemical compounds and environmental pollutants are relevant etiologic factors. Systemic sclerosis (SSc, scleroderma) belongs to diseases of connective tissue, characterized by chronic inflammation developing on an autoimmune background. The current state of knowledge on the etiopathogenesis of autoimmune diseases indicates the existence of many factors affecting the development of the disease, including factors of the external environment. Considering all the above, a study on a role of genetic polymorphisms of glutathione <jats:italic>S<\/jats:italic>\u2010transferase has been undertaken in which predisposition to SSc in a Polish population was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was carried out in 161 subjects: 61 patients with SSc and 100 healthy volunteers. A determination of the polymorphism of <jats:italic>GSTM1<\/jats:italic> and <jats:italic>GSTT1<\/jats:italic> was performed with a multiplex PCR (polymerase chain reaction). The <jats:italic>GSTP1<\/jats:italic> polymorphism was determined by using the PCR restriction fragment length polymorphism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The risk of developing SSc was 3\u2010fold higher for persons with the <jats:italic>null GSTM1<\/jats:italic> and <jats:italic>GSTT1<\/jats:italic> genotypes (odds ratio [OR]\u00a0=\u00a03.3; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0051). The risk for SSc was also demonstrated to be over 2.5\u2010fold greater in the <jats:italic>GSTP1 Ile\/Val<\/jats:italic> genotype individuals (OR\u00a0=\u00a02.62; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0037). Carriers of the <jats:italic>GSTP1 Val<\/jats:italic> variant allele had a greater than 2\u2010fold increase in SSc risk (OR\u00a0=\u00a02.41; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The genetic polymorphism of glutathione <jats:italic>S<\/jats:italic>\u2010transferase may affect the risk of SSc in a Polish population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13712","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T05:03:02Z","timestamp":1571720582000},"page":"2119-2124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Analysis of genetic polymorphisms of glutathione <i>S<\/i>\u2010transferase (GSTP1, GSTM1, and GSTT1) in Polish patients with systemic sclerosis"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3807-8984","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Bara\u0144ska","sequence":"first","affiliation":[{"name":"Department of Pharmacogenetics Medical University of \u0141\u00f3d\u017a \u0141\u00f3d\u017a Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariola","family":"Rychlik\u2010Sych","sequence":"additional","affiliation":[{"name":"Department of Pharmacogenetics Medical University of \u0141\u00f3d\u017a \u0141\u00f3d\u017a Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jadwiga","family":"Skr\u0119tkowicz","sequence":"additional","affiliation":[{"name":"Department of Pharmacogenetics Medical University of \u0141\u00f3d\u017a \u0141\u00f3d\u017a Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u0142","family":"Dudarewicz","sequence":"additional","affiliation":[{"name":"Department of Pharmacogenetics Medical University of \u0141\u00f3d\u017a \u0141\u00f3d\u017a Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo\u017cena","family":"Dziankowska\u2010Bartkowiak","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Medical University of \u0141\u00f3d\u017a \u0141\u00f3d\u017a Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Owczarek","sequence":"additional","affiliation":[{"name":"Department of Pharmacogenetics Medical University of \u0141\u00f3d\u017a \u0141\u00f3d\u017a Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daria","family":"Orszulak\u2013Michalak","sequence":"additional","affiliation":[{"name":"Department of Biopharmacy Medical University of \u0141\u00f3d\u017a \u0141\u00f3d\u017a Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u017cbieta","family":"Waszczykowska","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Medical University of \u0141\u00f3d\u017a \u0141\u00f3d\u017a Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-415813-9.00003-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2014.133"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026013395001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2353\/jmoldx.2007.070030"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(01)00206-8"},{"key":"e_1_2_6_7_1","first-page":"814","article-title":"Combination Effect of GSTM1, GSTT1 and GSTP1 polymorphisms and risk of systemic lupus erythematosus","volume":"44","author":"Salimi S","year":"2015","journal-title":"Iran J Public Health"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389200003339117"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5718(99)00167-9"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920006778017786"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1998.1708"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(99)00230-1"},{"key":"e_1_2_6_13_1","first-page":"509","article-title":"Transferase S\u2010glutathione class p gene (GSTP1) polymorphism in thyroid cancer patients","volume":"5","author":"Marciniak P","year":"2006","journal-title":"Pol J Endocrinol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2003.01975.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.8.693"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363756"},{"issue":"4","key":"e_1_2_6_17_1","first-page":"3","article-title":"One year in review 2017: systemic sclerosis","volume":"106","author":"Barsotti S","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-016-3533-1"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13203"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199003293221302"},{"key":"e_1_2_6_21_1","first-page":"45","article-title":"Genetic polymorphism of glutathione s\u2010transferase as a factor predisposing to allergic dermatitis","volume":"52","author":"Lutz W","year":"2001","journal-title":"Med Pr"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(99)00220-9"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38098"},{"key":"e_1_2_6_24_1","first-page":"3855","article-title":"Glutathione S\u2010transferase T1, M1 and P1 genetic polymorphisms and susceptibility to colorectal cancer in Turkey","volume":"17","author":"Gorukmez O","year":"2016","journal-title":"Asian Pac J Cancer Prev"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v10.i23.3389"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/64334"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1568-9972(03)00057-0"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.02.079"},{"key":"e_1_2_6_29_1","first-page":"1477","article-title":"Micronutrient antioxidant status in patients with primary Raynaud\u2019s phenomenon and systemic sclerosis","volume":"21","author":"Herrick AL","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70014-K"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203304lu1012ed"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206940"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.45.120403.095857"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10955"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.04.013"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200104)44:4<981::AID-ANR158>3.0.CO;2-0"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-014-3496-8"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mgene.2015.12.002"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-509X.178408"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/2047-783X-17-17"},{"key":"e_1_2_6_41_1","first-page":"27","article-title":"Genetic risk factors for chronic obstructive pulmonary disease","volume":"132","author":"Joos L","year":"2002","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2009.10.003"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200312-1763OC"},{"key":"e_1_2_6_44_1","first-page":"1829","article-title":"Genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes and lung cancer risk","volume":"10","author":"Dialyna IA","year":"2003","journal-title":"Oncol Rep"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(03)00076-X"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-199908000-00008"},{"key":"e_1_2_6_47_1","first-page":"15","article-title":"Glutathione S\u2010transferase genetic polymorphisms and human diseases: overview of epidemiological studies","volume":"62","author":"Habdous M","year":"2004","journal-title":"Ann Biol Clin (Paris)"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.13712","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.13712","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.13712","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T22:51:02Z","timestamp":1694213462000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.13712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,21]]},"references-count":46,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/1756-185X.13712"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.13712","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"type":"print","value":"1756-1841"},{"type":"electronic","value":"1756-185X"}],"subject":[],"published":{"date-parts":[[2019,10,21]]},"assertion":[{"value":"2019-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}