{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:59:46Z","timestamp":1789595986102,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T00:00:00Z","timestamp":1571270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Polymyalgia rheumatica (PMR) is a systemic inflammatory disease in the elderly of unknown etiology. While glucocorticoids are the mainstay of treatment for PMR, various glucocorticoid\u2010related adverse events are common. Recently, several studies have reported the efficacy of tocilizumab (TCZ), an anti\u2010interleukin\u20106 receptor antibody, for PMR treatment in addition to an accompanying reduction, or even tapering\u2010off, of glucocorticoids in some cases. The objective of this study was to elucidate the efficacy of TCZ monotherapy in the absence of glucocorticoids for PMR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We conducted a 2\u2010year, prospective, single\u2010center, open\u2010label pilot study of TCZ monotherapy in patients with PMR. TCZ (8\u00a0mg\/kg) was administered at fortnightly intervals for the first 2\u00a0months and monthly over the next 10\u00a0months. Subsequently, patients were observed for another year without any treatment. The primary endpoints were the remission rates at weeks 12 and 52, and the secondary endpoints were the relapse rate and safety over the total 104\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen patients were included in this study. Four of these patients achieved remission at week 12 (remission rate 31%). Four patients withdrew from the study due to adverse events (n\u00a0=\u00a02) and inefficacy (n\u00a0=\u00a02). At week 52, all 9 patients who had completed the first year achieved remission. Eight patients completed the drug\u2010free second year, with 7 maintaining remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TCZ monotherapy is well tolerated and can lead to remission in most patients with PMR in the absence of glucocorticoids.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13723","type":"journal-article","created":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T05:48:00Z","timestamp":1571377680000},"page":"2151-2157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Tocilizumab monotherapy for polymyalgia rheumatica: A prospective, single\u2010center, open\u2010label study"],"prefix":"10.1111","volume":"22","author":[{"given":"Kentaro","family":"Chino","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Saitama Medical Center Saitama Medical University Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuneo","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Saitama Medical Center Saitama Medical University Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Saitama Medical Center Saitama Medical University Saitama Japan"},{"name":"Department of Microbiology and Immunology Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuntaro","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Saitama Medical Center Saitama Medical University Saitama Japan"},{"name":"Division of Rheumatology Department of Internal Medicine Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Saitama Medical Center Saitama Medical University Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Saitama Medical Center Saitama Medical University Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiko","family":"Kurasawa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Saitama Medical Center Saitama Medical University Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Okuyama","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Saitama Medical Center Saitama Medical University Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Takei","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Saitama Medical Center Saitama Medical University Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4228-2056","authenticated-orcid":false,"given":"Koichi","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Saitama Medical Center Saitama Medical University Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/AITC201705020"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31825-1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39333"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-014-2650-y"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110851"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.140266"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/29.6.456"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.103663"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.091185"},{"key":"e_1_2_7_11_1","first-page":"w13156","article-title":"Rapid induction of remission in large vessel vasculitis by IL\u20106 blockade. 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