{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T18:20:32Z","timestamp":1767982832929,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501418"],"award-info":[{"award-number":["81501418"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, and osteitis) is an autoimmune disease of unknown etiology that seriously affects patients' daily lives. Family\u2010based investigations support genetic contributions toward disease susceptibility. The present study evaluated whether the previously reported autoimmune disease\u2010associated single nucleotide polymorphisms (SNPs) have any genetic overlap with SAPHO syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Genomic DNA was obtained from 71 SAPHO patients and 104 healthy controls. The SNP genotypes of each patient were determined with polymerase chain reaction and matrix\u2010assisted laser desorption\/ionization time\u2010of\u2010flight mass spectrometry (MALDI\u2010TOF MS). Genotype, allele, and haplotype frequencies were analyzed with SPSS software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three SNP sites (rs10889677 and rs2201841 of interleukin [IL]\u201023R, and rs2243248 of IL\u20104) showed significant correlation with the occurrence of SAPHO syndrome in additive and dominant genetic models, while rs7517847 of IL\u201023R showed substantial correlation with SAPHO in the dominant genetic model. The G allele of rs2243248 (IL\u20104) was a high risk factor for SAPHO (<jats:italic>P<\/jats:italic>\u00a0=\u00a02.41e\u22125, odds ratio [OR] =7.79, 95% CI: 2.59\u201023.3). The haplotype (A\u2010G\u2010C\u2010G\u2010T), comprising 5 SNPs of the IL\u201023R gene, had a significantly higher frequency in the SAPHO cohort than in the controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.011, OR\u00a0=\u00a02.05, 95% CI: 1.12\u20103.60).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Variants rs10889677, rs2201841, and rs7517847 of IL\u201023R, and variant rs2243248 of IL\u20104, showed strong associations with SAPHO syndrome. Patients carrying the A\u2010G\u2010C\u2010G\u2010T haplotype of IL\u201023 are significantly more likely to develop SAPHO syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13741","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T09:59:07Z","timestamp":1573207147000},"page":"2178-2184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association analysis of interleukin\u201023 receptor SNPs and SAPHO syndrome in Chinese people"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3840-9971","authenticated-orcid":false,"given":"Changlong","family":"Guo","sequence":"first","affiliation":[{"name":"National Research Institute for Family Planning Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Li","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feifei","family":"Han","sequence":"additional","affiliation":[{"name":"Beijing Chao\u2010Yang Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianen","family":"Gao","sequence":"additional","affiliation":[{"name":"National Research Institute for Family Planning Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Ma","sequence":"additional","affiliation":[{"name":"National Research Institute for Family Planning Beijing China"},{"name":"Beijing Chao\u2010Yang Hospital Beijing 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