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However, its anti\u2010inflammatory effects in autoimmune diseases such as lupus nephritis (LN) remain unclear. In this study, we want to investigate the therapeutic effect of \u03b1\u2010mangostin in LN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>First, we elucidated the retinoic acid receptor related orphan receptor gamma t (ROR\u03b3t) inhibitory activity of \u03b1\u2010mangostin in cell\u2010based assay and T helper 17 (Th17) differentiation in vitro assay. Then, we established a pristane\u2010induced LN mouse model and randomly divided these into a normal control group, model control group, \u03b1\u2010mangostin group and prednisone acetate group. Finally, anti\u2010double\u2010stranded DNA (anti\u2010dsDNA) level in serum was detected by enzyme\u2010linked immunosorbent assay, interleukin (IL)\u201017A and interferon (IFN)\u2010\u03b3 expression in spleen cells by flow cytometry; histomorphology examination of kidneys was performed by periodic acid\u2010Schiff staining and immunofluorescence analysis with an anti\u2010immunoglobulin G (anti\u2010IgG) and anti\u2010IgM antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that \u03b1\u2010mangostin inhibited ROR\u03b3t transcription activity in a cell\u2010based assay and also polarized Th17 cells in an in vitro induction experiment. Our results also showed that \u03b1\u2010mangostin could significantly decrease serum anti\u2010dsDNA antibody levels, IL\u201017A and IFN\u2010\u03b3 expression and alleviate renal pathological damage in the \u03b1\u2010mangostin\u2010treated group mice than in the model group mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Thus, \u03b1\u2010mangostin demonstrated its potential as a candidate therapeutic drug for LN and other Th17\u2010mediated autoimmune diseases by inhibiting the function of Th17.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13743","type":"journal-article","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T06:05:58Z","timestamp":1574748358000},"page":"74-83","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["\u03b1\u2010mangostin attenuates pristane\u2010induced lupus nephritis by regulating Th17 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