{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T04:52:20Z","timestamp":1749099140873,"version":"3.40.5"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T00:00:00Z","timestamp":1576713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Inflammatory arthritis including rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are disorders at increased risk of morbidity and mortality for which a validated prognostic tool for facilitating clinical management is needed. CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc (congestive heart failure\/hypertension\/age diabetes\/stroke\/vascular disease\/age\/sex category) score was initially conceived and used to estimate thromboembolic risk in non\u2010valvular atrial fibrillation, and then successfully applied in community populations with sinus rhythm. We tested CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc\u2010score as a prognosticator of adverse outcomes in patients in sinus rhythm with RA\/AS\/PsA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between March 2014 and March 2015, 414 patients (214 RA, 75 AS, 125 PsA) in sinus rhythm without cardiac disease were consecutively analyzed and prospectively followed\u2010up. Primary and co\u2010primary end\u2010points were a composite of all\u2010cause death\/all\u2010cause hospitalization and CV death\/CV hospitalization, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients were divided into LOWscore and HIGHscore groups if CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc was\u00a0=\u00a00\/1 point or greater than 1 point, respectively. The HIGHscore group comprised 190 patients who were older with higher prevalence of CV risk factors and arthritis disease activity than 224 LOWscore patients. During a follow up of 36\u00a0months, the event rate for primary and co\u2010primary end\u2010point was 37% and 12% in the HIGHscore vs 22% and 4% in LOWscore group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001 and .002 respectively). At multivariate Cox regression analysis CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc\u2010score was related to primary end\u2010point (hazards ratio [HR] 1.30 [1.07\u20101.59], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.009) and co\u2010primary end\u2010point (HR 1.35 [1.01\u20101.79], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04) independently of traditional CV risk factors analyzed individually and indexes of inflammation or disease duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc\u2010score accurately identifies in the mid\u2010term patients in sinus rhythm with RA\/AS\/PsA at different risks for CV and non\u2010CV mortality and hospitalization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13751","type":"journal-article","created":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T13:00:37Z","timestamp":1576760437000},"page":"106-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Usefulness of CHA<sub>2<\/sub>DS<sub>2<\/sub>\u2010VASc score to predict mortality and hospitalization in patients with inflammatory arthritis"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2805-9982","authenticated-orcid":false,"given":"Giovanni","family":"Cioffi","sequence":"first","affiliation":[{"name":"Rheumatology Section Department of Medicine University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ombretta","family":"Viapiana","sequence":"additional","affiliation":[{"name":"Rheumatology Section Department of Medicine University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Orsolini","sequence":"additional","affiliation":[{"name":"Rheumatology Section Department of Medicine University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Idolazzi","sequence":"additional","affiliation":[{"name":"Rheumatology Section Department of Medicine University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Fracassi","sequence":"additional","affiliation":[{"name":"Rheumatology Section Department of Medicine University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Ognibeni","sequence":"additional","affiliation":[{"name":"Rheumatology Section Department of Medicine University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Dalbeni","sequence":"additional","affiliation":[{"name":"Department of Medicine General Medicine and Hypertension Unit University of Verona and Azienda Ospedaliera Universitaria Integrata of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Gatti","sequence":"additional","affiliation":[{"name":"Rheumatology Section Department of Medicine University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Carletto","sequence":"additional","affiliation":[{"name":"Rheumatology Section Department of Medicine University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Fassio","sequence":"additional","affiliation":[{"name":"Rheumatology Section Department of Medicine University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Rossini","sequence":"additional","affiliation":[{"name":"Rheumatology Section Department of Medicine University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Giollo","sequence":"additional","affiliation":[{"name":"Rheumatology Section Department of Medicine University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22979"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24092"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2012.06.016"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2007.02.004"},{"key":"e_1_2_11_6_1","first-page":"2167","article-title":"Cardiovascular disease and risk factors in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis","volume":"33","author":"Han C","year":"2006","journal-title":"J Rheumatol"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezw313"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1093\/eurheartj\/ehy396","article-title":"Management of antithrombotic therapy in AF patients presenting with ACS and\/or undergoing PCI: A Summary of the Joint Consensus Document of the European Heart Rhythm Association (EHRA), European Society of Cardiology Working Group on Thrombosis, European Association of Percutaneous Cardiovascular Interventions (EAPCI) and European Association of Acute Cardiac Care (ACCA) endorsed by the Heart Rhythm Society (HRS), Asia\u2010Pacific Heart Rhythm Society (APHRS), Latin America Heart Rhythm Society (LAHRS), and Cardiac Arrhythmia Society of Southern Africa (CASSA)","volume":"39","author":"Lip GYH","year":"2018","journal-title":"Eur Heart J"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487317726068"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169095"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2016.10.008"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.10725"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2010.05.007"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-213378"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13110"},{"key":"e_1_2_11_17_1","first-page":"S75","article-title":"Scores for all seasons: SDAI and CDAI","volume":"32","author":"Smolen JS","year":"2014","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_11_18_1","first-page":"393","article-title":"Gruppo di Ricerca del Progetto CUORE. evaluation of the global cardiovascular absolute risk: the Progetto CUORE individual score","volume":"40","author":"Palmieri L","year":"2004","journal-title":"Ann Ist Super Sanita"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.180726"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487316649762"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2000.00337.x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211735"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-015-3101-0"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000040"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000437068.30550.cf"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.06.029"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000239694.19359.88"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204024"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.190261"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.09.027"},{"key":"e_1_2_11_31_1","first-page":"61","article-title":"Subclinical coronary artery calcification and relationship to disease duration in women with rheumatoid arthritis","volume":"35","author":"Kao AH","year":"2008","journal-title":"J Rheumatol"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000669"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-017-3588-7"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq232"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212862"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.485110"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.008714"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.13751","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.13751","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.13751","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.13751","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T11:36:34Z","timestamp":1694086594000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.13751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,19]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1111\/1756-185X.13751"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.13751","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"type":"print","value":"1756-1841"},{"type":"electronic","value":"1756-185X"}],"subject":[],"published":{"date-parts":[[2019,12,19]]},"assertion":[{"value":"2019-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}