{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:11:48Z","timestamp":1792588308773,"version":"4.5.0"},"reference-count":61,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,24]],"date-time":"2019-11-24T00:00:00Z","timestamp":1574553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/objective<\/jats:title><jats:p>Peripheral neuropathies (PN) are heterogeneous nerve disorders; frequently rheumatic patients have neuropathic symptoms. In some rheumatic diseases (RD) PN are secondary to nerve compression while others are related to metabolic abnormalities, inflammation or vasculitis. Our aim was to explore the frequency of neuropathic symptoms with three neuropathy questionnaires (NQ) and nerve conduction studies (NCS) in RD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a cross\u2010sectional study in patients with any RD attending for the first time to a rheumatology outpatient clinic. We included all patients who accepted to participate and who answered three NQ and received a physical evaluation. Twenty patients were randomly selected to perform NCS and 10 healthy subjects were included as controls. The topographic diagnoses were: mononeuropathy, multiplex mononeuropathy, and\/or polyneuropathy. Statistical analysis: descriptive statistics (mean, median, standard deviation, interquartile range and frequency, odds ratios and Pearson correlation test).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred patients and 10 healthy subjects were included. Sixty\u2010nine were female, mean age 40.6\u00a0\u00b1\u00a015.7\u00a0years. Rheumatic diagnoses were: systemic lupus erythematosus (26%), rheumatoid arthritis (16%), gout (14%), and osteoarthritis (11%). Fifty\u2010two patients had neuropathic signs during physical examination and 67% had positive questionnaires with variable scores among several RD. Abnormal NCS was reported in 14 patients (70%): 6 (42.8%) median nerve mononeuropathies, 4 (28.5%) multiplex mononeuropathies and 4 (28.5%) polyneuropathies. None of the healthy subjects had neuropathy (NQ, physical evaluation, or NCS). Risk of being NCS positive is higher when the patients were NQ positive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PN has variable distribution and high frequency in patients with RD; NQ+ increases the risk of presenting NCS+ for PN.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13755","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T07:19:35Z","timestamp":1574666375000},"page":"226-232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Peripheral neuropathies in rheumatic diseases: More diverse and frequent than expected. A cross\u2010sectional study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7027-8409","authenticated-orcid":false,"given":"Carlos Omar","family":"L\u00f3pez\u2010L\u00f3pez","sequence":"first","affiliation":[{"name":"Rehabilitation Department Hospital General de M\u00e9xico Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria de la Luz","family":"Montes Castillo","sequence":"additional","affiliation":[{"name":"Rehabilitation Department Hospital General de M\u00e9xico Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Carina","family":"Soto\u2010Fajardo","sequence":"additional","affiliation":[{"name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le\u00f3n Felipe","family":"Sandoval\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Rheumatology Department Hospital General 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