{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:27:41Z","timestamp":1790519261340,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T00:00:00Z","timestamp":1575504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Health, Labor and Welfare of Japan"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Systemic sclerosis (SSc) is an autoimmune disease characterized by skin and lung fibrosis. Although SSc has a high mortality risk, an effective treatment for the disease has not been established yet. Mesenchymal stromal\/stem cells (MSCs) are multipotential nonhematopoietic progenitor cells that have the ability to regulate immune responses. Adipose\u2010derived stromal\/stem cells (ASCs), one of the types of MSCs, have the advantage of accessibility and potent immunomodulatory effects when compared with other MSCs, such as bone marrow\u2010derived MSCs. This study aimed to investigate the antifibrotic effect of ASCs in scleroderma mouse models, including bleomycin\u2010induced scleroderma and sclerodermatous chronic graft\u2010versus\u2010host disease (Scl\u2010cGVHD) models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>ASCs were intravenously administered to a bleomycin\u2010induced scleroderma or Scl\u2010cGVHD model on day 0. We compared the skin and lung fibrosis of scleroderma model mice between the ASC\u2010treated group and control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Administration of ASCs attenuated the skin and lung fibrosis of bleomycin\u2010induced scleroderma and Scl\u2010cGVHD model mice compared to that in the control mice. Immunohistochemical staining showed that ASCs suppressed the infiltration of CD4<jats:sup>+<\/jats:sup>, CD8<jats:sup>+<\/jats:sup> T cells and macrophages into the dermis of bleomycin model mice compared to that in control mice. In addition, ASCs attenuated the messenger RNA expression of collagen and fibrogenic cytokines, such as interleukin (IL)\u20106 and IL\u201013, in the skin of bleomycin model mice. ASCs also reduced the frequency of fibrogenic cytokine\u2010producing CD4<jats:sup>+<\/jats:sup> T cells and effector B cells in the spleen of bleomycin model mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ASCs could prove to be a potential therapeutic agent for use in patients with SSc.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13764","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T03:16:34Z","timestamp":1575602194000},"page":"216-225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Adipose\u2010derived stromal\/stem cells successfully attenuate the fibrosis of scleroderma mouse models"],"prefix":"10.1111","volume":"23","author":[{"given":"Ai","family":"Okamura","sequence":"first","affiliation":[{"name":"Department of Dermatology Kanazawa University Graduate School of Medical Sciences Kanazawa Japan"},{"name":"Department of Plastic Surgery Kanazawa University Hospital Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1617-086X","authenticated-orcid":false,"given":"Takashi","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kanazawa University Graduate School of Medical Sciences Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akito","family":"Komuro","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kanazawa University Graduate School of Medical Sciences Kanazawa Japan"},{"name":"Department of Plastic Surgery Kanazawa University Hospital Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadahiro","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kanazawa University Graduate School of Medical Sciences Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kanazawa University Graduate School of Medical Sciences Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhito","family":"Hamaguchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kanazawa University Graduate School of Medical Sciences Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Takehara","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kanazawa University Graduate School of Medical Sciences Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,5]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"53","article-title":"Hypothesis for the pathogenesis of systemic sclerosis","volume":"48","author":"Furst DE","year":"1997","journal-title":"J Rheumatol Suppl"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.5301\/jsrd.5000249"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14153"},{"issue":"2","key":"e_1_2_8_5_1","first-page":"308","article-title":"Serum levels of interleukin 6 (IL\u20106), oncostatin M, soluble IL\u20106 receptor, and soluble gp130 in patients with systemic sclerosis","volume":"25","author":"Hasegawa M","year":"1998","journal-title":"J Rheumatol"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2017.1356722"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aas9944"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2018.11.008"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.226"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5411.143"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxx008"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-015-1915-9"},{"issue":"2","key":"e_1_2_8_13_1","first-page":"195","article-title":"[Mesenchymal stem cell therapy in hematopoietic stem cell transplantation]. 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