{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:36:52Z","timestamp":1793144212201,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T00:00:00Z","timestamp":1575590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"crossref","award":["UL1TR002377"],"award-info":[{"award-number":["UL1TR002377"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Eosinophilic fasciitis (EF) is a rare, fibrosing disorder of skin and subcutaneous tissue. This study was undertaken to describe its clinical and laboratory features and identify prognostic factors associated with outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective review of all EF patients evaluated at our institution from 1 January1997 to 30 December 2016. Kaplan\u2010Meier methods were used to determine treatment response rates over time. Potential associations between baseline characteristics and complete response were examined using Cox models adjusted for age and sex. Time\u2010dependent covariates were used to examine treatment effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 89 EF patients, with a female\u2010to\u2010male ratio of 1:1. Clinical features included groove sign in 26 (29%), peau d'orange\/dimpling in 22 (25%), inflammatory arthritis in 9 (10%) and muscle weakness in 9 (10%). Aldolase was elevated in 11\/36 (31%). Complete response rate was 60% (95% confidence interval [CI]: 35\u201075) at 3\u00a0years. Diagnostic delay was inversely associated with treatment response (hazards ratio: 0.84 per 1\u00a0month increase; 95% CI: 0.73\u20100.98). No baseline characteristics correlated with treatment response, but a trend toward positive association of elevated aldolase, hypergammaglobulinemia and presence of hematologic disorders was noted. Methotrexate was the most commonly used immunosuppressant in 79%, hydroxychloroquine in 45%, mycophenolate mofetil in 18% and azathioprine in 8%. No single immunosuppressant agent was associated with a superior response during treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>EF is characterized by relatively high response rates. Consensus diagnostic criteria, standardized management algorithms, and large prospective multi\u2010center cohorts are needed to develop an evidence\u2010directed approach to this challenging condition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13770","type":"journal-article","created":{"date-parts":[[2019,12,7]],"date-time":"2019-12-07T05:28:58Z","timestamp":1575696538000},"page":"233-239","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Baseline characteristics and long\u2010term outcomes of eosinophilic fasciitis in 89 patients seen at a single center over 20\u00a0years"],"prefix":"10.1111","volume":"23","author":[{"given":"Robert L.","family":"Mango","sequence":"first","affiliation":[{"name":"Essentia Health Duluth Clinic Duluth MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kubra","family":"Bugdayli","sequence":"additional","affiliation":[{"name":"MetroHealth Medical Center Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia S.","family":"Crowson","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Medicine Mayo Clinic College of Medicine Rochester MN USA"},{"name":"Department of Health Sciences Research Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Drage","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Wetter","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia S.","family":"Lehman","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic College of Medicine Rochester MN USA"},{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margot S.","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic College of Medicine Rochester MN USA"},{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4626-2412","authenticated-orcid":false,"given":"Vaidehi R.","family":"Chowdhary","sequence":"additional","affiliation":[{"name":"Section of Rheumatology, Allergy and Immunology Yale University School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,6]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"70","article-title":"Diffuse fasciitis with eosinophilia: a new syndrome?","volume":"88","author":"Shulman LE","year":"1975","journal-title":"Trans Assoc Am Physicians"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90257-0"},{"issue":"1","key":"e_1_2_7_4_1","first-page":"27","article-title":"Eosinophilic fasciitis: report of 15 cases","volume":"56","author":"Michet CJ","year":"1981","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(88)90008-X"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.03544.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker366"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.06.148"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2000.15.3.346"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3182899e78"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hemonc.2013.12.003"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-006-0525-6"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.05.018"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.3648"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.184.3.01840975"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12499"},{"issue":"2","key":"e_1_2_7_17_1","first-page":"493","article-title":"Eosinophilic fasciitis. 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