{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:29:51Z","timestamp":1790281791615,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T00:00:00Z","timestamp":1575936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373219"],"award-info":[{"award-number":["81373219"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["[JC2019009]"],"award-info":[{"award-number":["[JC2019009]"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To measure the levels of serum interleukin (IL)\u201034 in patients with primary Sj\u00f6gren's syndrome (pSS) and evaluate the cytokine's clinical association with the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum samples were obtained from 66 pSS patients and 32 healthy controls (HCs) and measured by enzyme\u2010linked immunosorbent assay for IL\u201034 levels. The clinical parameters, including autoantibodies, immunoglobulins (Igs), complements (Cs), inflammatory indicators, involvement of the blood system, lung and arthritis, were collected simultaneously. Two\u2010sample <jats:italic>t<\/jats:italic> test was applied for comparison between 2 groups, and Pearson's correlation coefficient was used to assess the associations between IL\u201034 levels and laboratory parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum IL\u201034 levels were significantly elevated in pSS patients compared with HCs. Patients with anti\u2010Ro\/SSA antibody positivity showed higher serum IL\u201034 levels than those who were negative, as did the anti\u2010La\/SSB antibody\u2010positive patients. Serum IL\u201034 levels were positively associated with the levels of rheumatoid factor, IgG and gamma\u2010globulin, but not associated with IgA, IgM, C3, C4, erythrocyte sedimentation rate or C\u2010reactive protein. For the pSS subgroups with and without leucopenia, thrombocytopenia, anemia or interstitial lung disease (ILD), there was no significant difference in serum IL\u201034 levels. Interestingly, the pSS patients with arthritis had higher levels of IL\u201034 compared with the no\u2010arthritis patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IL\u201034 may be involved in B cell activation and production of antibodies in pSS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13773","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T07:12:12Z","timestamp":1576048332000},"page":"374-380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Serum levels of interleukin\u201034 and clinical correlation in patients with primary Sj\u00f6gren's syndrome"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3071-906X","authenticated-orcid":false,"given":"Yanmei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Rheumatology The 1st Affiliated Hospital of China Medical University 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