{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T02:07:19Z","timestamp":1777860439702,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T00:00:00Z","timestamp":1579046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate susceptible human leukocyte antigen (HLA) alleles and their associations with clinical features in Thai patients with Beh\u00e7et's disease (BD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Eighteen HLA\u2010A and 36 HLA\u2010B alleles were determined in 42 Thai BD patients and 99 healthy controls (HCs) by reverse line blot assay, and reconfirmed by MICRO SSP assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The BD patients had significantly higher allele frequency (AF) of HLA\u2010B*51 than the HCs (13.10% vs 5.05%,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.025). The AF of HLA\u2010A*26, \u2010A*26:01 and \u2010B*51:01 also was higher and almost reached statistical significance (5.59% vs 1.52%,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.054, 5.95% vs 1.52%,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.054 and 10.71% vs 4.04%,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.051, respectively). However, the BD patients had significantly higher AF of either HLA\u2010A*26:01 or \u2010B*51:01 (16.67% vs 5.56%,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.005), or \u2010A*26:01 or \u2010B*51X (19.05% vs 6.56%,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.003). The AF of HLA\u2010B*51:01 and \u2010B*51X increased significantly in \u2010A*26:01 non\u2010carrier BD patients (12.16% vs 4.17%,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.024 and 14.86% vs 5.21%,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.019, respectively); and that of HLA\u2010A*26:01 was significantly higher in \u2010B*51X non\u2010carrier BD patients (7.58% vs 1.67%,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.034). HLA\u2010B*51:01 associated significantly with the presence of posterior uveitis and visual impairment (18.18% vs 2.50%,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.031 for both conditions). HLA\u2010B*51:01 was not observed in BD patients with gastrointestinal involvement or arthritis. Furthermore, the AF of HLA\u2010B*51:01 was significantly higher in HLA\u2010A*26:01 non\u2010carrier BD patients without arthritis (17.30% vs 0%,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.050).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HLA\u2010B*51:01 was a susceptible allele for Thai BD patients, and associated with posterior uveitis and visual impairment. HLA\u2010A*26:01 was another susceptible allele in HLA\u2010B*51X non\u2010carrier patients. The protective effect of HLA\u2010B*51:01 on arthritis needs further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13785","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T06:23:41Z","timestamp":1579155821000},"page":"247-255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Contribution of HLA\u2010B*51:01 and \u2010A*26:01 to Beh\u00e7et's disease and their clinical association in Thai patients"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3105-6122","authenticated-orcid":false,"given":"Worawit","family":"Louthrenoo","sequence":"first","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Faculty of Medicine Chiang Mai University Chiang Mai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuntana","family":"Kasitanon","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Faculty of Medicine Chiang Mai University Chiang Mai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kessara","family":"Pathanapitoon","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Faculty of Medicine Chiang Mai University Chiang Mai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suparaporn","family":"Wangkaew","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Faculty of Medicine Chiang Mai University Chiang Mai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"Kuwata","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Faculty of Medicine Teikyo University School of Medicine Ichihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai","family":"Nishi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The University of Tokyo Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshikatsu","family":"Kaburaki","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Graduate School of Medicine The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rie","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The University of Tokyo Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fujio","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (Allergy and Rheumatology) Faculty of Medicine University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.1999.540301.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24642"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3292"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03335.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.108571"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2006.00586.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(98)80001-2"},{"key":"e_1_2_11_9_1","first-page":"S182","article-title":"Epidemiology of Behcet's disease in Thai patients","volume":"89","author":"Arromdee E","year":"2006","journal-title":"J Med Assoc Thai"},{"issue":"4","key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"510","DOI":"10.47102\/annals-acadmedsg.V33N4p510","article-title":"Behcet's disease: experience in a tertiary rheumatology centre in Singapore and a review of the literature","volume":"33","author":"Cheng YK","year":"2004","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12107"},{"key":"e_1_2_11_12_1","unstructured":"Blindness and visual impairment 2018. 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