{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:20:03Z","timestamp":1779895203716,"version":"3.53.1"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T00:00:00Z","timestamp":1580169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether magnetic resonance imaging (MRI) pathologies in the wrist\/hand of rheumatoid arthritis (RA) patients are associated with patient\u2010reported outcomes (PROs) at clinical remission and relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Wrist\/hand MRIs and wrists\/hands\/feet radiographs were obtained in 114 established RA patients in clinical remission, before tapering their biologic disease\u2010modifying antirheumatic drugs. MRIs were assessed according to the Outcome Measures in Rheumatology (OMERACT) RA MRI score (RAMRIS) for inflammation (synovitis\/tenosynovitis\/bone marrow edema) and damage (bone erosion\/joint space narrowing) at baseline (ie remission) and in case of a relapse (n\u00a0=\u00a070). Radiographs were assessed according to the Sharp\/van der Heijde (SvH) method at baseline. These scores were assessed for associations with health assessment questionnaires (HAQ), visual analog scales (VAS global\/pain), EuroQol\u20105 dimensions and Short\u2010Form 36 physical and mental component summary (SF\u201036 PCS\/MCS) using Spearman correlations, univariate\/multivariable linear regression analyses and generalized estimating equations. Furthermore, MRI pathologies were assessed for association with specific hand\u2010related HAQ items using Jonckheere trend tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Magnetic resonance imaging\u2010assessed damage was associated with impaired HAQ and SF\u201036 PCS at remission and relapse (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01), independent of clinical and radiographic measures, and was also associated with most of the hand\u2010related HAQ items (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.03). In multivariate models including MRI, SvH scores were not associated with PROs. MRI\u2010assessed inflammation was not associated with PROs at remission or relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Magnetic resonance imaging\u2010assessed wrist\/hand damage, but not inflammation, in patients with established RA is associated with patient\u2010reported physical impairment at remission and relapse. The amount of damage in the wrist\/hand is associated with reduced hand function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13790","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T07:11:06Z","timestamp":1580281866000},"page":"488-498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association between MRI findings and patient\u2010reported outcomes in patients with rheumatoid arthritis in clinical remission and at relapse"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0452-8200","authenticated-orcid":false,"given":"Daniel","family":"Glinatsi","sequence":"first","affiliation":[{"name":"Copenhagen Center for Arthritis Research (COPECARE) Center for Rheumatology and Spine Diseases Centre of Head and Orthopaedics Rigshospitalet Glostrup Denmark"},{"name":"Department of Rheumatology Skaraborg Hospital Sk\u00f6vde Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilie H.","family":"Brahe","sequence":"additional","affiliation":[{"name":"Copenhagen Center for Arthritis Research (COPECARE) Center for Rheumatology and Spine Diseases Centre of Head and Orthopaedics Rigshospitalet Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merete L.","family":"Hetland","sequence":"additional","affiliation":[{"name":"Copenhagen Center for Arthritis Research (COPECARE) Center for Rheumatology and Spine Diseases Centre of Head and Orthopaedics Rigshospitalet Glostrup Denmark"},{"name":"The DANBIO Registry Copenhagen Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lykke","family":"\u00d8rnbjerg","sequence":"additional","affiliation":[{"name":"Copenhagen Center for Arthritis Research (COPECARE) Center for Rheumatology and Spine Diseases Centre of Head and Orthopaedics Rigshospitalet Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Krabbe","sequence":"additional","affiliation":[{"name":"Copenhagen Center for Arthritis Research (COPECARE) Center for Rheumatology and Spine Diseases Centre of Head and Orthopaedics Rigshospitalet Glostrup Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua F.","family":"Baker","sequence":"additional","affiliation":[{"name":"Corporal Michael J. Crescenz VA Medical Center University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Boesen","sequence":"additional","affiliation":[{"name":"Department of Radiology Copenhagen University Hospital Frederiksberg Frederiksberg Denmark"},{"name":"The Parker Institute Copenhagen University Hospital Frederiksberg Frederiksberg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoreh","family":"Rastiemadabadi","sequence":"additional","affiliation":[{"name":"Department of Radiology Copenhagen University Hospital Frederiksberg Frederiksberg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone","family":"Morsel\u2010Carlsen","sequence":"additional","affiliation":[{"name":"Department of Radiology Copenhagen University Hospital Frederiksberg Frederiksberg Denmark"},{"name":"Department of Radiology Rigshospitalet Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"R\u00f8gind","sequence":"additional","affiliation":[{"name":"Copenhagen Center for Arthritis Research (COPECARE) Center for Rheumatology and Spine Diseases Centre of Head and Orthopaedics Rigshospitalet Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Hansen","sequence":"additional","affiliation":[{"name":"Center for Rheumatology and Spine Diseases Copenhagen University Hospital Gentofte Gentofte Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"N\u00f8rregaard","sequence":"additional","affiliation":[{"name":"Center for Rheumatology and Spine Diseases Nordsj\u00e6llands Hospital Hiller\u00f8d Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"},{"name":"Copenhagen Lupus and Vasculitis Clinic Center for Rheumatology and Spine Diseases Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene","family":"Terslev","sequence":"additional","affiliation":[{"name":"Copenhagen Center for Arthritis Research (COPECARE) Center for Rheumatology and Spine Diseases Centre of Head and Orthopaedics Rigshospitalet Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuan K.","family":"Huynh","sequence":"additional","affiliation":[{"name":"Center for Rheumatology and Spine Diseases Nordsj\u00e6llands Hospital Hiller\u00f8d Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Manilo","sequence":"additional","affiliation":[{"name":"Center for Rheumatology and Spine Diseases Copenhagen University Hospital Frederiksberg Frederiksberg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorte V.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Copenhagen Center for Arthritis Research (COPECARE) Center for Rheumatology and Spine Diseases Centre of Head and Orthopaedics Rigshospitalet Glostrup Denmark"},{"name":"The DANBIO Registry Copenhagen Denmark"},{"name":"Center for Rheumatology and Spine Diseases Copenhagen University Hospital Gentofte Gentofte Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob M.","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"},{"name":"Department of Radiology Copenhagen University Hospital Herlev Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels S.","family":"Krogh","sequence":"additional","affiliation":[{"name":"Zitelabs Aps Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikkel","family":"\u00d8stergaard","sequence":"additional","affiliation":[{"name":"Copenhagen Center for Arthritis Research (COPECARE) Center for Rheumatology and Spine Diseases Centre of Head and Orthopaedics Rigshospitalet Glostrup Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200343"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201620"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.161097"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.141009"},{"issue":"6","key":"e_1_2_7_6_1","first-page":"1385","article-title":"Rheumatoid Arthritis Magnetic Resonance Imaging Studies. 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