{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:56:38Z","timestamp":1786989398774,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,26]],"date-time":"2020-01-26T00:00:00Z","timestamp":1579996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The findings regarding association of <jats:italic>endoplasmic reticulum aminopeptidase 1<\/jats:italic> (<jats:italic>ERAP1<\/jats:italic>) gene polymorphisms and ankylosing spondylitis (AS) susceptibility are inconsistent. Our aim is to appraise and merge the existing evidence on the relationship of <jats:italic>rs27044<\/jats:italic> and <jats:italic>rs30187<\/jats:italic> polymorphisms in <jats:italic>ERAP1<\/jats:italic> gene and susceptibility to AS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Electronic databases of PubMed, Web of Science, EMBASE, Cochrane Library, Wanfang, and CNKI were retrieved for relevant publications. The search was conducted from inception to 10 June, 2019. Studies on the association of <jats:italic>rs27044<\/jats:italic> and <jats:italic>rs30187<\/jats:italic> polymorphisms and risk of AS were included. Quality evaluation was carried out using Newcastle\u2010Ottawa Scale (NOS). Summary odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to appraise the associations under allelic and genotypic models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 26 case\u2010control studies with 31 cohorts containing 17\u00a0223 AS patients and 36\u00a0915 controls were eligible for this meta\u2010analysis. According to NOS, each study received\u00a0\u2265\u00a05 scores. The pooled data indicated that <jats:italic>rs27044<\/jats:italic> and <jats:italic>rs30187<\/jats:italic> polymorphisms were significantly associated with AS susceptibility in the overall population: <jats:italic>rs27044<\/jats:italic>, G versus C, OR\u00a0=\u00a01.24, 95% CI 1.16\u20101.33, <jats:italic>P&lt;<\/jats:italic>.001; <jats:italic>rs30187<\/jats:italic>, T versus C, OR\u00a0=\u00a01.24, 95% CI 1.17\u20101.33, <jats:italic>P&lt;<\/jats:italic>.001. When stratified by ethnicity, <jats:italic>rs27044<\/jats:italic> appeared to be significantly correlated with AS in both Asians and Caucasians. For <jats:italic>rs30187<\/jats:italic>, despite positive association being observed under the allelic model in both Asians and Caucasians, the findings of genotypic comparisons supported the association only existed in Caucasians but not Asians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggests that <jats:italic>rs27044<\/jats:italic> and <jats:italic>rs30187<\/jats:italic> polymorphisms are significantly associated with increased risk of AS, especially in Caucasians.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13795","type":"journal-article","created":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T04:59:39Z","timestamp":1580101179000},"page":"499-510","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Association of <i>rs27044<\/i> and <i>rs30187<\/i> polymorphisms in <i>endoplasmic reticulum aminopeptidase 1<\/i> gene and ankylosing spondylitis susceptibility: 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