{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:36:53Z","timestamp":1792204613807,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T00:00:00Z","timestamp":1580169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to investigate the relationship between the level of serum signal peptide\u2010CUB\u2010EGF domain\u2010containing protein (SCUBE)\u20101, SCUBE\u20102 and SCUBE\u20103 and clinical findings and ultrasonographic skin thickness in systemic sclerosis (SSc).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Thirty patients who met the American College of Rheumatology\/European League against Rheumatism 2013 SSc classification criteria and 44 healthy volunteers who were compatible with the patient group in terms of age and gender were included in the study. Serum SCUBE levels were measured by enzyme\u2010linked immunosorbent assay. Ultrasonographic skin thickness measurements were simultaneously performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant difference was found between the serum SCUBE levels of SSc patients and serum SCUBE levels of the control group. A negative correlation was detected between serum SCUBE\u20101 level and forced expiratory volume in 1\u00a0second (FEV<jats:sub>1<\/jats:sub>). While a positive correlation was detected between serum SCUBE\u20102 level and the Duru\u00f6z Hand Index and serum C4 level, a negative correlation was determined with the forced vital capacity (FVC) value. A negative correlation was determined between serum SCUBE\u20103 level and echocardiographic pulmonary artery pressure (PAP). A correlation could not be determined between serum SCUBE levels and ultrasonographic skin thickness. However, a positive correlation was observed between ultrasonographic skin thickness and the modified Rodnan skin score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study, a correlation was observed between serum SCUBE levels and some clinical and laboratory parameters (FEV<jats:sub>1<\/jats:sub>, FVC, PAP, C4, and Duru\u00f6z Hand Index) in SSc patients. New clinical studies are needed to better understand the contribution of these molecules in the progression and pathogenesis of SSc.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13798","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T00:29:19Z","timestamp":1580257759000},"page":"526-531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The relationship of serum SCUBE\u20101, \u20102 and \u20103 levels with clinical findings and ultrasonographic skin thickness in systemic sclerosis patients"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8431-7184","authenticated-orcid":false,"given":"\u0130brahim","family":"G\u00fcnd\u00fcz","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Diyarbak\u0131r Gazi Ya\u015fargil E\u011fitim Ara\u015ft\u0131rma Hastahanesi Diyarbak\u0131r 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